酒精性肝病患者血清m-AST的变化及临床意义  

Serum Mitochondrial Aspartate Aminotransferase Isoenzyme Alterations and Its Clinical Significance in Patients With Alcoholic Liver Disease

作　　者：陈辉[1] 戴春梅[1] 郑兰香[1] 

机构地区：[1]中南大学湘雅三医院检验科,湖南长沙410013

出　　处：《实用预防医学》2005年第6期1317-1318,共2页Practical Preventive Medicine

摘　　要：目的探讨酒精性肝病(ALD)患者血清天门冬氨酸氨基转移酶线粒体同工酶(m-AST)活性的变化及临床意义。方法采用m-AST免疫比浊法测定63例ALD患者,30例健康人血清中m-AST活性水平,并计算出与天门冬氨酸氨基转移酶(L-AST)活性的比值及m-AST升高百分比。结果ALD患者血清m-AST活性水平显著高于正常人(P<0.01),入院2周酒精性脂肪肝(AFL)患者病情好转者,血清m-AST水平下降(P<0.01),酒精性肝炎(AH))及酒精性肝硬化(AC)患者下降不显著(P>0.05)。结论血清m-AST活性的测定及m-AST/L-AST比值可作为ALD的早期诊断及判断病情和预后的良好指标。Objective To study the alterations and clinical significance of serum mitochondrial aspartate aminotransferase isoenzyme in patients with alcoholic liver disease （ALD）. Methods The levels of the serum m-AST activity in 63 patients with ALD and 30 health controls were measured by the method of immunoturbidimetry assay, and the ratio of m-AST to L-AST activities and the percent increments of m - AST were calculated and analyzed. Results The serum m - AST level of the patients of ALD was evidently higher than the healthy controls （P〈0.01）. After 2 weeks of admission, the level of m-AST in serum decreased markedly in those of alcoholic fatty liver being improved （P〈 0.01）, but not in those with alcoholic hepatitis and alcoholic cirrhosis （P〉0.05）. Conclusion The activity of serum m-AST and the ratio of m-AST to L- AST can be regarded as an indicator for early diagnosis and prognosis for ALD.

关 键 词：酒精性肝病 天门冬氨酸氨基转移酶线粒体同工酶 测定 

分 类 号：R575[医药卫生—消化系统]