高渗氯化钠羟乙基淀粉40注射液对失血性休克大鼠小肠粘膜NF-κB影响的实验研究  

Study of the Effects on Hypertonic Sodium Chloride Hydroxyethyl Starch 40 Injection to Intestinal Mucosal Microcirculation nuclear factor-Kappa B in Hemorrhagic Shock Rats

作　　者：王少文[1] 闻兆章[2] 刘洪涛[2] 郝立强[2] 郑成竹[2] 

机构地区：[1]石家庄白求恩国际和平医院普外科,050082 [2]第二军医大学长海医院普外科,200433

出　　处：《中国医药导刊》2005年第6期448-450,共3页Chinese Journal of Medicinal Guide

摘　　要：为探讨高渗氯化钠羟乙基淀粉40注射液(Hypertonic Sodium chloride Hydroxyethyl starch 40 injection,HSH)对小肠 粘膜核因子-K appa B(NF-κB)的影响,以SD大鼠为实验对象,分别检测休克前,重度休克后以及以HSH和林格氏 液复苏后不同时间点小肠粘膜NF-κB表达情况。结果显示失血后小肠粘膜内炎细胞浸润增加,并出现糜烂和溃疡,小 肠粘膜内炎症细胞和腺细胞NF-κB的表达明显增加,给予HSH复苏后,小肠粘膜形态明显改善,表达NF-κB的细胞恢 复至休克前水平,给予林格氏液复苏组小肠粘膜损伤进一步加重,NF-κB的表达进一步增加。结论:失血性休克发生后, 小肠组织中NF-κB的表达迅速增强,其表达程度与炎性细胞的浸润程度及损伤程度一致,RL复苏可增强肠道组织中NF- κB的表达。HSH能快速抑制肠道组织中NF-κB的表达。To study the effects of Hypertonic Sodium chloride Hydroxyethyl starch 40 injection（HSH） treating shock,the intestinal mucosal nuclear factor Kappa B （NF-kB） of Sprague-Dawley（SD） rats are tested befor and after serve hemorrhagic shock resuscitation with Lactated Ringer solution and Hypertonic Sodium chloride Hydroxyethyl starch 40 injection.conclutions：the expression of intestinal mucosal NF-kB increase rapidly after hemorrhagic shock; Lactated Ringer solution can increase expression of intestinal mucosal NF-kB,while Hypertonic Sodium chloride Hydroxyethyl starch 40 iniection can decrease the expression.

关 键 词：休克 出血性 高渗液 NF-KB 肠道 

分 类 号：R605.971[医药卫生—急诊医学]