利用广义线性方法定位家畜抗性等级性状的QTL  

Mapping Quantitative Trait Loci for Ordinal Traits of Disease Resistance Using Generalized Linear Method

作　　者：殷宗俊[1] 张勤[2] 张纪刚[2] 丁向东[2] 

机构地区：[1]安徽农业大学动物科技学院,合肥230036 [2]中国农业大学动物科技学院,北京100094

出　　处：《畜牧兽医学报》2005年第12期1241-1246,共6页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家重点基础研究发展规划(G2000016103);国家杰出青年科学基金(30025003);安徽省教育厅基金(2002jq126;2004kj151);安徽省自然基金(050410204)

摘　　要：在广义线性模型的框架内模拟研究了家畜抗性等级性状的QTL定位方法,QTL参数的估计采用最大似然方法,比较了阈模型方法与一般线性方法的QTL定位效率,并对影响等级性状QTL定位效率的主要因素(QTL效应、性状的遗传力)进行了模拟研究。试验为多个家系的女儿设计,资源群体大小为500头。结果表明:在QTL位置参数估计及检验功效方面,阈模型方法具有一定的优势,对抗性等级性状QTL定位的功效也高于线性方法。另外,性状遗传力和QTL效应的大小对QTL定位的准确度也有直接的影响,随着性状遗传力QTL效应的增大,2种方法QTL定位的效率均有不同程度的提高。Methodology of QTL mapping for ordinal traits of disease resistance basing on the framework of a generalized linear model （GLM） was present in the paper. The location and effect parameters of putative QTL were estimated using Maximum Likelihood method. The efficiency and power were compared with the linear model （LM）. The factors of influencing QTL detection efficiency （e. g. QTL effect and heritability） were simulated in our study too. Daughter design with multiple families was applied, and the number of segregating population is 500. The results showed that threshold model have a great advantage in location estimation and power of QTL mapping, and have nice efficiency and accuracy for ordinal traits. In addition, the accuracy of QTL mapping depended on the effect of putative quantitative trait loci and the value of heritability. With the increase of QTL effect and heritability, the accuracy of QTL mapping improved slightly.

关 键 词：抗性等级性状 阈模型 线性模型 QTL定位 最大似然法 

分 类 号：S813.1[农业科学—畜牧学]