nm23基因表达与喉鳞癌发展相关性研究  

Expression of nm23 gene in laryngeal squamous cell carcinoma

作　　者：吴正虎[1] 张宇伟[1] 张振华[1] 费声重[1] 

机构地区：[1]浙江医科大学附属第一医院耳鼻咽喉科,浙江医科大学病理科,中国医科大学

出　　处：《临床耳鼻咽喉科杂志》1996年第5期259-261,共3页Journal of Clinical Otorhinolaryngology

摘　　要：应用免疫组织化学方法对３６例喉鳞癌患者的ｎｍ２３基因产物／核苷二磷酸激酶（ｎｍ２３／ＮＤＰＫ）进行检测。结果：喉鳞癌中ｎｍ２３／ＮＤＰＫ表达的阳性率为６９．４％（２５／３６）；随着肿瘤的增大及淋巴结转移的出现，ｎｍ２３表达程度降低，Ｔ１－２病变高于Ｔ３－４病变；Ⅰ～Ⅱ期喉癌高于Ⅲ～Ⅳ期喉癌；无颈淋巴结转移者高于颈淋巴结转移者（Ｐ＜０．０５）。ｎｍ２３／ＮＤＰＫ表达与肿瘤生长部位及病理分级无关。表明ｎｍ２３基因低表达可能是肿瘤进展和颈淋巴结转移的相关因素。Using immunohistochemical technique to detect the expression of antimetastatic gene in laryngeal squamous cell carcinoma in 36 cases. Of these 25(69.4%)cases showed immunoreactivity in nm23/NDPK. Statistical analysis revealed that the decreases in expresion of nm23/NDPK was significantly correlated with cervical lymph node metastasis and with advanced stages of laryngeal carcinoma( P <0. 05), No relationship was found among nm23/NDPK expression,histopathological grades and tumor sites. The results suggest that nm23 gene may play a role in the mechanism of tumor progression and the development of regional metastasis from these tumors.

关 键 词：喉肿瘤 NM23 基因 核苷二磷酸激酶 鳞癌 

分 类 号：R739.650.3[医药卫生—肿瘤] R730.3[医药卫生—临床医学]