芍药甘草汤治疗高催乳素血症对照研究  

Controlled study of shaoyao-gancao decoction and bromicripton in hyperprolactinemia

作　　者：袁海宁[1] 王传跃[1] 冯秀杰[1] 刘瑞玫[1] 张继志[1] 

机构地区：[1]首都医科大学附属北京安定医院,100088

出　　处：《临床精神医学杂志》2005年第6期337-338,共2页Journal of Clinical Psychiatry

摘　　要：目的:探讨芍药甘草汤对女性精神分裂症患者应用利培酮后出现高催乳素血症的疗效。方法:对女性精神分裂症患者以利培酮治疗后催乳素水平≥50μg/L伴月经稀发或闭经者纳入交叉对照研究,共18例。利培酮继续原有剂量,先后合并芍药甘草汤或溴隐亭治疗各4周,间隔4周,总疗程12周。测定血清催乳素、雌二醇、睾酮、孕酮浓度,评定阳性与阴性症状量表(PANSS)和副反应量表(TESS)。结果:芍药甘草汤或溴隐亭治疗均可降低催乳素浓度(P<0.01),服芍药甘草汤后催乳素浓度平均降低(18.0±24.3)μg/L;服溴隐亭后平均降低(25.3±24.4)μg/L,二者相仿(t=-1.054,P>0.05);经治疗9例患者月经来潮。结论:芍药甘草汤可用于治疗利培酮所致的高催乳素血症,未见明显不良反应。Objective： To explore the efficacy of shaoyao-gancao decoction in the treatment of hyperprolactinemia in female schizophrenics induced by rispefidone. Method： 18 female schizophrenic patients with risperidone were enrolled into the cross-over study. Their serum prolactin levels were above 50 μg/L and had oligomenorrhoea or amenorrhoea. They were assigned randomly into two sessions with an interval of 4 weeks on fixed continual risperidone dosage. In the control session bromicripton was taken for 4 weeks first, while in the study session shaoyao-gancao decoction was taken first for 4 weeks. The total duration was 12 weeks. Serum hormones （ prolactin, estradiol, testostenme,progesterone） and clinical status [positive and negative symptom scale （PANSS）, treatment emergant sympton scale （TESS）] were examined. Results： Both of shaoyao-gancao decoction and bromicripton can obviously reduced the prolactin levels of female schizophrenics（ P 〈 0.01 ）. Compared with control session, shaoyao-gancao decoction produced the same decrease （ t = - 1. 054, P 〉 0.05 ） The average reduction with shaoyao-gancao decoction was （ 18.0 ± 24.3）μL, while with bromicripton the number was （25.3 ± 24.4）μL. Nine of the patients had their menses recovered. Conclusion： Shaoyao-gancao decoction would be benefit in treating risperidone-induced hyperprolactinemia.There would be not any obvious adverse events.

关 键 词：芍药甘草汤 高催乳素血症 精神分裂症 利培酮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]