大豆异黄酮对小鼠脑组织中胆碱酯酶和氨基酸类神经递质及记忆的影响  

Effects of Soy Isofiavones on Brain AChE and Amino Acid Neurotransmitters and Memory of Mice

作　　者：辛天蓉[1] 刘燕强[1] 吕宪禹[1] 任自立[1] 赵强[1] 

机构地区：[1]南开大学生命科学学院

出　　处：《南开大学学报（自然科学版）》2005年第6期18-21,共4页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：教育部留学人员科研启动基金资助项目

摘　　要：采用不同剂量的大豆异黄酮饲喂小鼠,观测大豆异黄酮对小鼠记忆功能、脑组织中氨基酸类神经递质含量、脑组织与血液中胆碱酯酶活性的影响.结果表明,实验所用的三个剂量(30、60、120 m g/kg.bw)的大豆异黄酮对小鼠的记忆能力均有不同程度的提高;大豆异黄酮使小鼠血液和海马中胆碱酯酶(AChE)活性以及大脑皮质与海马组织中甘氨酸(G ly)含量降低,而大脑皮质与海马组织中天冬氨酸(A sp)和谷氨酸(G lu)含量升高.此结果提示,大豆异黄酮具有调节脑组织中氨基酸类神经递质和胆碱酯酶代谢的作用,这可能与大豆异黄酮调节记忆功能有关.This experiment was designed to examine the effects of different dosages of soy isoflavones on memory, neurotransmitters （Glu, Asp and Gly） content in brain, acetylcholinesterase （ACHE） activity in blood and hippocampus of mice. The results showed that good memory function of mice resulted from treatment of three dosages （30,60,120 mg/kg · bw） of soy isoflavones. Meanwhile, AChE activity in hippocampus and blood, and the Gly content in cerebral cortex and hippocampus of mice were decreased, whereas, Asp and Glu contents in cerebral cortex and hippocampus were increased by soy isoflavones. The results suggested that soy isoflavones modulation of AChE and some neurotransmitters （Glu, Asp and Gly） in brain tissues correlated with memory function of experimented mice.

关 键 词：大豆异黄酮 记忆 氨基酸 胆碱酯酶 

分 类 号：Q427[生物学—神经生物学]