榄香烯静脉输注浓缩液体外抗人体肿瘤细胞疗效实验研究  

Anti-tumour activity of concentrated elemene injection in vitro

作　　者：窦玉琴 刘玉欣 严惠芳[2] 陆宏祺[2] 

机构地区：[1]大连市医药科学研究所,辽宁大连116013 [2]上海医药工业研究院药理室,上海200437

出　　处：《大连医科大学学报》2005年第6期421-423,共3页Journal of Dalian Medical University

摘　　要：[目的]了解榄香烯静脉输注浓缩液的体外抑瘤效果。[方法]用CremophorEL作增溶剂配合丙二醇制成2%榄香烯静脉输注浓缩液,进行体外细胞增殖抑制实验(MTT活细胞染色法)。[结果]榄香烯静脉输注浓缩液体外细胞毒实验对多种人体肿瘤细胞:SHG-44人体神经胶质瘤、LAX人体肺腺癌、HL-60人白血病、人体肝细胞癌QGY及人体胃癌MGC,IC50依次为56.07～60.47μg/mL、88.76～92.80μg/mL、39.37～40.14μg/mL、90.26～100.82μg/mL、61.29～83.64μg/mL。[结论]榄香烯静脉输注浓缩液对上述人体肿瘤细胞具有一定的增殖抑制作用。[Objective] To study the inhibitory effect of concentrated elemene injection on cancer cells in vatro. [ Method]Five cell lines of SHG - 44, LAX, HL - 60, QGY and MGC. The concen the elemene injection with concentrativen of 2%, then cell proliferation inhibitory of concentrated elemene injection by M TT live cell staining method.[Results] Cell proliferation inhibitory rates of SHG- 44, LAX, HL- 60, QGY and MGC, the IC50 were 56.07 - 60.47 μg/mL, 88.76 - 92.80 μg/mL, 39.37 - 40.14 μg/mL, 90. 26 - 100.82 μg/mL and 61.29- 83.64 μg/mL respectively. [ Conclusion] Concentrated elemene injection could inhibit proliferation of some tumor cells in vatro.

关 键 词：榄香烯静脉输注浓缩液 MTT活细胞染色法 SHG-44人体神经胶质瘤 肺腺癌 HL-60人白血病 人体肝细胞癌QGY 人体胃癌MGC 

分 类 号：R73-36[医药卫生—肿瘤]