Pre-S_2抗原在乙肝病毒隐性感染中的地位与应用研究  

Status of Pre-S_2 antigen in hepatitis B virus' s inapparent infection and application research.

作　　者：王剑[1] 盘晓娟[1] 林永富[1] 吴德荣[1] 吴阿阳[2] 刘平娥[3] 唐冬英[3] 彭丽花[3] 蒋光清[3] 陈友元[3] 

机构地区：[1]漳州医学护理职业学院,福建漳州363000 [2]漳州市医院,福建漳州363000 [3]永州职业技术学院,湖南永州425006

出　　处：《临床肝胆病杂志》2005年第6期331-332,共2页Journal of Clinical Hepatology

摘　　要：探讨Pre-S2抗原在乙型肝炎病毒的各类隐性感染中的地位及科研、临床应用价值。以乙肝病毒隐性感染者作为研究对象,采用ELISA法,同时检测感染者的Pre-S2抗原和“乙肝血清标志物(HBV M)”,然后进行各类感染者之间的比较、分析。在乙肝病毒隐性感染者人群中,HBeAg阳性者、HBeAb阳性者的Pre-S2抗原阳性率分别为93．10％、60．00％;“乙肝大三阳”、“小三阳”者的Pre-S2抗原阳性率分别为92．31％、62．50％。Pre-S2抗原在判断乙肝病毒复制、隐性感染者血清的传染性强度方面,有很高使用价值和补缺作用;在判断隐性感染者的发展转化方面,亦有重大参考意义。To study status and use value of Pre-S2 antigen in different types of hepatitis B vires＇ s inapparent infections in scientific reseach and clinical work. Enzyme linked immunosorbent assay was used to detect hepatitis B vires＇s inapparent infecters＇ Pre -S2 andgen and HBV M in different classification, then compared and analysed them. In hepatitis B vires＇ s inapparent infecter crowds, positive rates of Pre-S2 antigen were 93.10% and 60.00% respectively to HBeAg positive people and HBeAb positive people. People of “Hepatitis B Large- three- positive”and “Small- three- positive”, their positive rates of Pre-S2 antigen were 92.31% and 62.50% separately. Pre -S2 antigen has greatest use value and addendum function of judge hepatitis B vires＇s replication and inapparent infecters＇ serous infectious strength. It also has great reference significance to judge hepatitis B inapparent infecters＇ change.

关 键 词：前S2抗原 乙肝病毒 隐性感染 

分 类 号：R512.62[医药卫生—内科学]