成年脑内的神经发生与抑郁症  

Neurogenesis in the adult brain and depression

作　　者：刘琼[1] 俞瑾[1] 吴根诚[1] 

机构地区：[1]复旦大学上海医学院中西医结合系,上海200032

出　　处：《神经科学通报》2005年第6期436-440,共5页Neuroscience Bulletin

基　　金：the National Natural Science Foundation(NO:30371798); the Foundation of Ministry of Education(NO:20020246043).

摘　　要：哺乳动物成年后中枢神经系统内仍存在神经发生,成体脑内神经发生的调节因素及其与海马的功能联系是目前研究的热点。海马作为成体脑内神经发生最为活跃的区域之一,对各种应激刺激也最为敏感。同时,海马是参与情绪调控的主要脑区之一,是抑郁症机制研究的结构基础。影响神经发生的许多因素同时也和抑郁症的病因与预后有关。目前成体脑内神经发生和抑郁症的关系已成为抑郁症机制研究的新方向。Neurogenesis can be observed in the adult nervous system of many mammals. It is a popular topic about the regulation and functional reconstruction of adult neurogenesis. As one of the most active areas where neurogenesis occurs, hippocampus is most sensitive to stressful stimulations. Moreover, hippocampus plays a critical role in emotion controlling and may be the basis of research of depression. In addition, many regulative factors of neurogenesis may be involved in the etiology and therapy of depression. At present, the relationship between adult brain neurogenesis and depression should be a new focus for the research of depression.

关 键 词：神经发生 抑郁症 海马 

分 类 号：R749.4[医药卫生—神经病学与精神病学]