环丙沙星大黄治疗急性重症胰腺炎与IL-6 IL-8相关性的实验研究  

The Experimental Study on the Relative Relationship between Antibiotics Ciprofloxacin for the Matching with the Crude Rhubarb Used for the Treatment of SAP and IL-6、IL-8 in Serum.

作　　者：赖少彤[1] 金琦[2] 邓兆斌[1] 李靖华[1] 蒋俊明[3] 

机构地区：[1]大连大学附属医院消化内科,辽宁大连116021 [2]佳木斯大学第一临床医院,黑龙江佳木斯154007 [3]四川大学华西医学中心,四川成都610041

出　　处：《中医药学刊》2005年第12期2174-2176,共3页Study Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局重点课题(92b093-9510)

摘　　要：目的:探讨应用环丙沙星与大黄治疗急性重症胰腺炎(SAP)与IL-6、IL-8相关性。方法:将实验动物随机分成3组:A-对照组(急性重症胰腺炎但未应用抗生素及中药组);B-SAP应用环丙沙星组;C-SAP应用中药+环丙沙星组。ELISA法(酶联免疫吸附法)检测IL-6、IL-8。结果:环丙沙星与大黄配伍可以明显下调SAP时各个时段IL-6、IL-8、血AMY水平,IL-6、IL-8与血AMY、胰腺湿重呈正相关,环丙沙星+大黄与环丙沙星组IL-6、IL-8与血AMY、胰腺湿重低于对照组。结论:环丙沙星+大黄治疗作用与降低IL-6、IL-8有关。Objective：To explore the relationship between SAP treated with Antibiotic Ciprofloxacin with crude rhubarb and IL-6、IL-8 in serum. Methods ： 165experienced SAP wistar mouse induced by injecting NaTC into pancreatic duct were at random divided into three groups： A-controled group; B-ciprofloxacin administered group; C-ciprofloxacin and crude rhbarb group level of IL-6、IL-8 and AMY in serum assayed by the Enzyme-linked immunosorbent assay. Results：Antibiotic Ciprofloxacin matching with crude rhubarb can decrease the level of IL-6、IL-8 and AMY in serum, level of IL-6、IL-8 and AMY, weigh of pancreas in Ciprofloxacin ＋ crude rhubarb group and Ciprofloxacin group is lower than in control group（P 〈 0.01 ）, There is obviously different in above mentioned two groups（ P 〈 0.05 ）. Conclusion ： The effect of both Ciprofloxacin plus crude rhubarb and Ciprofloxacin is associated of decrease IL-6、 IL-8 in serum.

关 键 词：急性重症胰腺炎 白细胞介素-6 白细胞介素-8 大黄 实验研究 

分 类 号：R576[医药卫生—消化系统]