形状记忆合金骨内植入后实验犬组织中镍钛含量的变化  

Changes of nickel and titanium in some organs and tissues of dogs after the en-dosseous implantation of shape memory alloy

作　　者：王海鹰[1] 鲍善芬[1] 李珍[1] 马良[1] 赵霖[1] 黄旭明[1] 

机构地区：[1]解放军总医院口腔科,解放军总医院微量元素室

出　　处：《军医进修学院学报》1996年第2期113-115,共3页Academic Journal of Pla Postgraduate Medical School

基　　金："八五"军队医药卫生科研基金

摘　　要：作者对８条体内分别植入１０颗镍钛形状记忆合金骨内种植体２～６个月的实验犬的肝、肾、脾及鼻咽粘膜中镍、钛含量的变化进行了分析，并以１０只同类犬作为对照。结果发现实验组犬的肝、肾、脾及鼻咽粘膜中镍含量均增高，除脾外均与对照组有显著差异（ｐ＜０．０５），其中肾有极显著的差异（Ｐ＜０．０１）；钛含量在上述各组织中均无显著变化。由此提示，镍钛形状记忆合金在动物体内的稳定性是相对的，但镍离子与钛离子的释放程度不同；镍在实验犬肝、肾及鼻咽粘膜中的这种增高趋势是否具有评价其生物安全度的意义尚需进一步研究；不同器官及组织对镍、钛的亲和力差异及其机制尚待深入探讨。The analyses were performed for the content of nickel and titanium in samples of liver,kidney,spleen and nasopharyngeal mucosa taken from eight dogs after irnplanting ten shape memory NiTi alloy en-dosseous dental implants in each dog for 2-6 months.Ten dogs were taken for the control.The results showed that,except spleens,there are significant increases for the content of nickel in all theorgans and tissues of experimental dogs(P<0.05),especially in kidneys(P<0.01);and no significant differ-ences for titanium in all the organs and tissues between the experimental group and the control.The results indicated that the stability of the shape memory NiTi alloy in animal bodys is relative, butthere are some variances in the released quantity between nickel and titanium;the further study should be tak-en to make clear the evaluation of biological safety for the tendency to increase the content of nickel in liver,kidney and nasopharyngeal mucosa of the experimental dogs;and the study also should be made in deep on themechanism and the differences of the affinity of various organs and tissues to nickel and titanium.

关 键 词：镍钛含量 记忆合金 骨内植入 狗 

分 类 号：R783.1[医药卫生—口腔医学]