DNA修复酶在胃癌组织中的表达变化及临床意义  

Study on the Expression of DNA Repairing Enzyme in the Gastric Carcinoma and Its Clinical Significance

作　　者：吴迎爽[1] 周宁[1] 程毅[1] 魏贵亮[1] 谢震[1] 祁贺[1] 薄爱华[1] 张晓丽[1] 邢立强[1] 

机构地区：[1]河北北方学院大学生科协,河北张家口075000

出　　处：《河北北方学院学报（医学版）》2005年第5期15-17,共3页Journal of Hebei North University:Medical Edition

摘　　要：目的:检测胃癌组织中DNA损伤修复酶(O6—甲基鸟嘌呤—DNA甲基转移酶O6—methylguanineDNA methyltransferase,MGMT)的表达变化,探讨其表达和胃癌临床病理特征之间的关系,进一步用于指导临床化疗方案的制定。方法:采用免疫组化方法(SABC法)检测55例胃癌标本中MGMT的表达情况。结果:MGMT在胃癌组织中的阳性表达率为43.64%(24/55),其阳性表达与年龄、病理类型有关,而与性别`、分化程度、侵犯深度、淋巴结转移的相关性不明显。结论:MGMT对胃癌化学治疗方案的制定有指导作用。Objective.. To investigate the expression change of DNA repairing enzyme MGMT in gastric carcinoma,and the relationship between the expression and pathologic charateristic,so as to guide making-up of treating plan. Methods.. Detect the expression of 55 cases with gastric carcinoma by SABC immunohisto-chemistry. Results：The positive expression rate of MGMT in the gastric carcinoma was 43.64% （24/55）. There was a signficant statistic difference between age and pathologic type in the expression of MGMT, but no obvious correlation among sex, defferentiation degree, invasion depth and lymphnode metastasis. Conclusion： The expression of MGMT can guide to make up a plan for treating gastric carcinoma.

关 键 词：胃癌 DNA损伤修复酶 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]