缺血性脑血管病患者血浆D－二聚体和GMP－140含量的变化及临床意义  

The determination and clinical significance of D dimer and Alpha granule membrane protein(GMP 140) in patients with ischemic cerebrovascular diseases.

作　　者：张晨[1] 郭英华[1] 赵慧元[1] 

机构地区：[1]青岛医学院附属医院神经内科 检验科

出　　处：《临床神经病学杂志》1996年第4期202-205,共4页Journal of Clinical Neurology

摘　　要：用ＥＬＩＳＡ双抗体夹心法和放射免疫法对７３例缺血性脑血管病患者血浆Ｄ－二聚体、血小板表面及血浆ＧＭＰ－１４０含量进行了测定。结果显示脑血栓形成（ＣＩ）急性期、恢复期和短暂性脑缺血发作（ＴＩＡ）患者血浆Ｄ－二聚体、血小板表面和血浆ＧＭＰ－１４０的含量均明显高于正常对照组（Ｐ＜０．００１）。ＴＩＡ伴有梗塞灶者无论血浆Ｄ－二聚体的含量还是血小板表面和血浆ＧＭＰ－１４０含量均显著高于无梗塞灶者（Ｐ＜０．０５，Ｐ＜０．００１，Ｐ＜０．０５）。结果提示缺血性脑血管病患者体内血液凝固性增强和血小板活化亢进。不仅对进一步了解缺血性脑血管病的发病机理和治疗提供了理论根据，而且对于观察病情演变。By using the enzyme linked immunosorbent assay and the radiommunoassay,the plasma concentrations of D dimer and Alpha granule mambrane protein(GMP 140) expressed on the surface of activated plateletes and in plasma were measured in 73 patients with ischemic cerebrovascular disease(ICVD).The results showed that the levels of D dimer,GMP 140 on the surface of activated plateletes and in plasma of these patients with TIA,acute and rehablitate of cerebral thrombosis were higher than those in the control group( P <0.001),The level of D dimer and GMP 140 on the surface of activated plateletes and plasma in these patients of TIA with infarction increased significantly than those TIA patients without infarction( P <0.05, P <0.001, P <0.05).Our findings suggested that enhanced activity of coagulation and fibvrinolysis exists and the plateletes were activated in ICVD.The measurement may be useful for study of the coagulation and fibrinolytic activities, differential diagnosis therapy,and prognosis in patients with ICVD.

关 键 词：D-二聚体 GMP-140 血浆 血小板 脑缺血 

分 类 号：R743.3[医药卫生—神经病学与精神病学]