岩消胶囊对小鼠肝癌抑制作用的实验研究  

Experimental study on inhibitory effect of yan xiao capsules on hepatocarcinoma mice

作　　者：杨广文[1] 郝志英[1] 

机构地区：[1]山西省肿瘤医院药剂科,太原030013

出　　处：《肿瘤研究与临床》2005年第6期385-387,共3页Cancer Research and Clinic

摘　　要：目的研究岩消胶囊对小鼠肝癌的抑制作用。方法选取40只小鼠,随机分为空白对照组、阳性对照组、实验组,分别观察实体瘤重量、小鼠存活时间、实体瘤的形态学和对腹水癌细胞的直接杀伤死亡率。结果实验组的实体瘤重量显著降低(P<0.01),抑瘤率达52.0%;小鼠存活时间明显延长,生命延长率81.6%(P<0.01);对腹水癌细胞有显著的杀伤作用(P<0.05)。结论岩消胶囊能显著抑制小鼠肝癌细胞移植性肿瘤的生长,减轻瘤体重量;能显著延长荷瘤小鼠生存期;同时对肿瘤细胞有直接杀伤作用。Objective To study the inhibitory effect of yan xiao capsules on hepatocarcinoma mice. Methods Forty mice were randomly divided into control group ,CTX group,ADM group,trial group. Observe tumour weight ,the span time of tumour-bearing mice, tumour morphology and the mortality rate of ascites cancer cell by direct killing respectively. Results The tumour weight markedly decreased in trial group, the rate of inhibition tumour was 52.0 %（P 〈0.01 ）; the span time of tumour-bearing mice were prolonged obviously, the rate of life prolongation was 81.6 %（P 〈0.01）; the killing was remarkable to ascites cancer cell（P 〈0.05）. Conclusions Yan xiao capsules could markedly inhibit the tumour growth of transplantable hepatocarcinoma cell, reduce the tumour weight, markedly prolong the span time of tumour-bearing mice. At the same time, Yan xiao capsules could directly kill tumour cell.

关 键 词：岩消胶囊 肝癌 实验肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]