胃癌单克隆抗体MGd1在胃癌免疫组化检查中的应用  

Immunohistochemical Study of Monoclonal Antibody MGd1 in Gastric carcinoma

作　　者：赵建业[1] 刘节[1] 杨淑杰[1] 樊代明[2] 

机构地区：[1]第四军医大学附属二院病理科 [2]第四军医大学附属一院消化内科

出　　处：《临床与实验病理学杂志》1989年第3期144-146,I001,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：本文报道采用MGd1胃癌单克隆抗体作ABC染色,检测胃癌、萎缩性胃炎等。61例胃癌中,54例阳性,阳性率8.5%,40例萎缩性胃炎,10例伴不典型增生,其中3例不典型增生上皮阳性,11例胃局部淋巴结转移癌,全部阳性,40例正常胃粘膜全为阴性。结果表明:MGd1胃癌单抗对胃癌有很高的特异性,可用于病理诊断。而胃癌的分化程度、浸润及转移能力与胃癌细胞内的相应抗原多少密切相关。This paper reports the results of routine pathological and immuno-histochemical examinations of 152 specimens by H E & ABC me-thods for monoclonal antibody (McAb) MGd1 of gastric carcino-ma. In 152 specimens 61 were gastric carcinoma & the positivecases of MGd1 were 54 & the detection-rate was 8.5%. 40 caseswere chronic gastritis in which 10 cases with atypical hyperplasia,3 cases of them were positive for MGd1 All 40 cases of anrmalgastric mucosa were negative & 11 cases of metastatic carcinoma oflocal lymph nodes were positive. These results showed that theMcAb MGd1 had high specificity for gastric carcinoma & could beused in pathologic diagnosis. It seems that there exists some rela-tionship between the differentiation, infiltration and metastatic abi-lity of gastric carcinoma cells & the amount of their related anti-gens.

关 键 词：粘膜活检 单克隆抗体 胃癌 胃镜 

分 类 号：R730.43[医药卫生—肿瘤]