尿激酶型纤溶酶原激活系统与卵巢恶性肿瘤  

uPA system and ovarian tumors

作　　者：王靖雯[1] 沈朝妍[2] 王伟[2] 程建新[1] 

机构地区：[1]河北医科大学第四医院妇产科,河北石家庄050011 [2]济宁市第一人民医院,山东济宁272111

出　　处：《国外医学（妇幼保健分册）》2005年第6期431-434,共4页Foreign Medical Sciences (Section of Maternal and Child Health)

摘　　要：肿瘤的侵袭转移是一多步骤、多因素参与的极其复杂的过程,涉及肿瘤细胞粘附、分离、迁移、基底膜及细胞外基质降解、肿瘤新生血管生成等诸多方面,其中尿激酶型纤溶酶原激活系统在卵巢恶性肿瘤侵袭转移中发挥了重要作用,现就尿激酶型纤溶酶原激活系统的相关研究概况及其进展作以综述。The invasion and metastasis of carcinoma is a complicated muhistep, muhifactorial process, involving cell adhesion, dissemination, motility, degradations of basal membrane and ECM, angiogenesis, ect. Of which, urokinase-type plasminogen activator （uPA） system was considered that it plays important roles in invasion and metastasis of malignant ovarian tumors. This article reviewed general situation and progress in relating researches on uPA system.

关 键 词：尿激酶型纤溶酶原激活物 尿激酶型纤溶酶原激活物受体 卵巢恶性肿瘤 侵袭转移 

分 类 号：R737.31[医药卫生—肿瘤]