甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的近期效果观察  

Effects of radiosensitizer metronidazole amino acidum natrium(CMNa) for non-small cell lung carcinoma

作　　者：陈国忠[1] 陈景林[1] 

机构地区：[1]福建医科大学附属第二医院放射治疗科,362000

出　　处：《福建医药杂志》2005年第6期31-32,共2页Fujian Medical Journal

摘　　要：目的观察甘氨双唑钠(CMNa)对非小细胞肺癌(NSCLC)放射治疗增敏作用的近期疗效。方法对32例经病理确诊的各期NSCLC作根治性常规放射治疗。放疗同时使用CMNa800mg/m2,每周3次(一、三、五);连续用药至放疗结束。放疗为标准时间分次方案:每次1.8～2Gy,每周5次。总剂量60～70Gy/6～7W。于放疗前、放疗后4周和7周,分别行CT或X线拍片。放疗中每周查血常规,每3周查肝肾功能及心电图。观察近期疗效及1年生存率。结果病人全部完成治疗,照射DT40Gy/4周时有效率(CR+PR率)为46.76%(15/32),治疗结束肿瘤局部缓解率87.5%(28/32)。病人不良反应发生率低,未观察到神经系统毒性。结论CMNa能提高NSCLC放射治疗的近期疗效,在使用过程中未发现不良反应,是一种低毒有效的放射增敏剂,其远期疗效尚需进一步研究。Objective To observe the early effects of radiosensitizer metronidazole amino acidum natrium （CMNa） for non-small cell lung carcinoma （NSCLC）. Methods From Nov 2002 to Oct 2003, 32 cases of non-small cell lung carcinoma （NSCLC） were treated with routine radiotherapy. Diagnosis in all cases was confirmed by pathology. The patients received intravenous CMNa 800mg/m^2 three times weekly during whole treatment period of radiotherapy. The standard protocols of radiotherapy were adopted in all the cases： DT 1.8-2 Gy/d, 5 d/W, and 60-70 Gy/6-7 W. The effects were assessed with CT scan or X-ray. Various blood routine tests were undergone weekly while the liver function, renal function and EKG were examined every three weeks. The early effects and 1-year survival rate were observed. Results All the patients completed the treatment. The rate of CR was 46.76% （15/32） after DT 40 Gy/4W, and 87.5% （28/32） after the treatment was over. The rate of adverse reaction was low. No neurotoxicity was observed. Conclusion CMNa is an effective radiosensitizer with low toxicity and high safety, which obviously enhanced the early effects of NSCLC, but the long-dated effects await further follow-up.

关 键 词：非小细胞肺癌 放射疗法 甘氨双唑钠 放射增敏剂 心电图 不良反应 

分 类 号：R734.2[医药卫生—肿瘤]