血管内皮生长因子及其受体在大鼠胃癌组织中的表达  

Expression of VEGF and its receptor in primary gastric cancer

作　　者：杨树才[1] 李玉兰[1] 李益民[1] 吕岩红[1] 徐晶莹[1] 肖建兵[1] 刘慧冬[1] 张雅芳[1] 

机构地区：[1]哈尔滨医科大学人体解剖学教研室,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2005年第6期487-488,491,F0004,共4页Journal of Harbin Medical University

基　　金：黑龙江省卫生厅科学技术研究项目(2004-170);黑龙江省科技厅攻关课题(GC03C606-1);黑龙江省教育厅科学技术研究项目(10511071)

摘　　要：目的探讨癌细胞淋巴道转移机制,观察VEGF-C及其受体Flt-4在大鼠胃癌组织中的表达。方法用免疫组化法检测大鼠胃癌组织的癌细胞和淋巴管内皮细胞对VEGF-C和Flt-4的表达。结果VEGF-C和Flt-4在癌细胞的胞浆均可见阳性表达;淋巴管内皮细胞上仅见到Flt-4的阳性表达。结论①Flt-4与VEGF-C在胃癌细胞的表达正相关,可能与肿瘤的浸润有关。②推测VEGF-C可能通过其受体Flt-4诱导胃癌组织淋巴管发生。Objective To explore the mechanism of lymphatic metastasis and the expression of VEGF-C and Flt-4 in rat gastric cancers. Methods Immunohistochemistry staining was performed to express VEGF-C and Flt-4 protein in rat cells and lymphatic endothelium of gastric cancer. Results VEGF-C and Flt-4 protein were expressed in the plasma of cancer cells. The expression of Flt-4 proteins were only showed in lymphatic endothelial cells, and significantly correlated with VEGF-C. Conclusion ①The positive correlation of VEGF-C and Flt-4 could make cancer developed.②It suggests that VEGF-C may induce lymphangiogenesis by its receptor Flt-4.

关 键 词：胃癌 血管内皮生长因子 FLT-4 大鼠 

分 类 号：R-332[医药卫生] R735.2