药物中间体7-氨基头孢烷酸的制备  

Production of the medicine intermedia of 7-ACA

作　　者：杨利敏[1] 王亚明[1] 张松[1] 钟莉[1] 邹文杰[1] 

机构地区：[1]昆明理工大学生物与化学工程学院,昆明650224

出　　处：《天津药学》2005年第6期1-2,共2页Tianjin Pharmacy

摘　　要：药物中间体7-氨基头孢烷酸(7-ACA)的工业化生产国内多局限于化学裂解法,由于该法有某些缺点,因此,本文介绍了环保型的酶法催化生产7-ACA的制备方法。该制备方法以头孢菌素C为起始原料,经固定化D-AOD氧化酶和GL-脱酰酶的作用,酶法裂解制得7-ACA,得到7-ACA的总收率达到74%。实验结果说明该方法是可行的,并且具有重要的现实意义。本文还对影响反应的因素做了进一步的讨论。In our cotmtry, the production of the medicine intermedia of 7 - ACA often limits to the chemic splitting decomposition produces. So this article introduced the 7 - ACA＇s environmental protection enzyme catalysis producing method. In this procedure, we use cephalosporin C as the outset raw material, through the function of fixed regularly to take bbD - AOD oxidase and enzyme of GL - 7 - ACA acylase, enzyme splitting decomposition produces 7 - ACA. Then we discussed the influencing factors in reacting.

关 键 词：7-氨基头孢烷酸 头孢菌素C 氧化酶 酰化酶 固定化 

分 类 号：R914.4[医药卫生—药物化学]