骨肿瘤组织P^(53)蛋白表达及临床意义的研究  

Expression of the p^(53) Protein in Bone Tumour and Its Clinical Meaning

作　　者：林建华[1] 许卫红[1] 朱维款 朱夏[1] 黄纲雄[2] 高凌云[2] 翁景萱[2] 

机构地区：[1]福建医学院附属第一医院骨科,350005 [2]福建医学院病理解剖教研室,350004

出　　处：《骨与关节损伤杂志》1996年第3期159-161,共3页The Journal of Bone and Joint Injury

摘　　要：应用抗P^(53)单克隆抗体免疫组织化学方法,检测了67例骨肿瘤组织标本P^(53)蛋白的表达.结果显示:20例骨肉瘤组织中有9例P^(53)蛋白表达阳性,而47例骨软骨瘤,骨巨细胞瘤均呈阴性反应.P^(53)蛋白表达与患者的性别,传统的骨肉瘤病理分型、大小、临床分期无明显相关.但P^(53)蛋白表达阳性的骨肉瘤患者预后比较差.The expression of p53 gene protein was analyzed in 67 cases of bone tumours by immunohistochemistry. The results showed 9(45 %)positive cases in 20 osteosarcomas. In contract 20 cases of osteochondroma and 27 cases of giant cell tumor of bone were completely negative. Expression of p53 protein showed no corelation with the patients sex、traditional pathological classification、size and clinical disease stage of osteosarcoma. The patients with positive stained had a worse prognosis than those with negatively stained.

关 键 词：骨肿瘤 P53蛋白 临床意义 

分 类 号：R738.102[医药卫生—肿瘤]