高压氧对颅脑损伤大鼠认知功能的影响  

Effects of Hyperbaric Oxygen in Rats with Cognitive Dysfunction after Traumatic Brain Injury

作　　者：尤春景[1] 秦杰[1] 黄杰[1] 秦开容[1] 陆敏[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院康复医学科,湖北武汉430030

出　　处：《中国康复》2005年第6期323-325,共3页Chinese Journal of Rehabilitation

基　　金：湖北省卫生厅科研基金项目(JXIB044)

摘　　要：目的:观察高压氧对颅脑损伤大鼠认知功能的影响。方法:30只SD大鼠采用Feeney自由落体撞击法造模,随机分为脑外伤组(A组)、脑外伤加高压氧治疗组(B组)和假手术对照组(C组)各10只,于造模24 d后同时在水迷宫内进行定位航行和空间搜索实验。结果:在相同时间点寻找水下平台的潜伏期,B组大鼠均少于A组;在空间搜索实验中,跨越水下平台位置的次数B组明显高于A组(均P<0.01)。结论:高压氧能够改善颅脑损伤大鼠学习记忆功能障碍,对神经功能具有保护作用。Objective： To observe the effect of hyperbaric oxygen（HBO） in rats with cognitive dysfunction after traumatic brain injury. Methods： The traumatic brain injury model was established by use of Feeney method in rats. Thirty male rats were recruited in this study and randomly divided into 3 groups： traumatic brain injury group （group A）, traumatic brain injury＋HBO group （group B）, and sham-operation group （group C）. The learning and memory in groups A, B and C were tested by Morris water maze 24 days after development of the model. Results： Rats in group B used less time than rats in group A in the latency of escape at the same time. In the spatial probe test, the times across the original platform in the group B were more than those in the group A. Conclusion： HBO treatment can effectively improve the cognitive dysfunction after traumatic brain injury.

关 键 词：脑外伤 高压氧 认知 水迷宫 

分 类 号：R749.1[医药卫生—神经病学与精神病学]