胃粘膜不典型增生MG7抗原表达的随访研究  

Following up study of MG7 antigen in gastric mucosa with dysplasia

作　　者：刘杰[1,2,3] 胡家露[1,2,3] 张沥[1,2,3] 林一帆[1,2,3] 樊代明[1,2,3] 曹晓燕[1,2,3] 张学庸[1,2,3] 

机构地区：[1]第四军医大学西京医院消化内科 [2]西安市中心医院 [3]沈阳军区总医院

出　　处：《第四军医大学学报》1996年第3期175-177,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：探讨ＭＧ７抗原在胃粘膜不典型增生癌变中的预测价值．方法：应用本院制备的抗胃癌单克隆抗体ＭＧ７作ＡＢＣ免疫组化染色，随访检测７２例胃粘膜异型增生标本．其中癌变组３４例，未癌变组３８例，随访时间６～７４个月（平均２８个月）．结果：癌变组中２４例表达阳性（７０．６％），未癌变组中仅７例呈阳性表达（１８．４％），两组相比差异非常显著（Ｐ＜０．０１）．在未癌变组ＭＧ７表达阴性的３１例标本中，随访后病变减轻或无变化者２９例，ＭＧ７－Ａｇ仍呈阴性表达；而未癌变组ＭＧ７表达阳性的７例中无一例病变减轻，此７例均呈增强表达．结论：ＭＧ７抗原表达阳性的胃粘膜不典型增生具有癌变倾向，ＭＧ７抗原表达阴性的病例具有可逆性．本研究将为进一步对ＭＧ７抗原定量，寻找高危癌变界值。Objective: To evaluate the value of MG7 antigen as possible indicator of malignant transformation in patients with dysplasia of gastric mucosa. Methods: 72 fully followed up patients with gastric dysplasia including 34 evolving into gastric cancer and 38 non canceration were studies by using ABC immunohistochemical method. Results: The expression of MG7 Ag were positive in 24 out of 34 cases with canceration (70.6%), only 7 out of 38 cases with no canceration, a significant statistical difference between two groups ( P <0.01). Reversion was found in 29 out of 31 cases in no canceration group with MG7 Ag negative staining. Conclusion: The positive expression of MG7 Ag may be of some value in assessing the potential for subsequent cancer in patients with dysplasia of gastric mucosa.

关 键 词：胃肿瘤 胃粘膜增生 异型增生 抗原 

分 类 号：R735.203[医药卫生—肿瘤]