早期分流手术对脑积水大鼠学习能力的影响  

Learning Deficits in Congenitally Hydrocephalic Rats and Prevantion by Early Shunt Treatment

作　　者：李守明[1] 刘昌英[2] 华学明[1] 吴浪龙[1] 

机构地区：[1]江西省儿童医院,江西南昌330006 [2]江西省医学实验动物中心,江西南昌330006

出　　处：《江西科学》2005年第6期727-729,763,共4页Jiangxi Science

摘　　要：研究先天性脑积水早期分流手术对学习能力的影响。采用分流术组及不实施手术治疗组,用morris水迷宫和旷场观察21 d时各组大鼠的空间学习能力,资料用one and two way AVONA和t-检验分析。在两组实施分流术的脑积水大鼠中,表现未见显著的不同,但与脑积水大鼠比较有显著意义。脑积水大鼠早期分流手术能显著提高学习能力,但是早期发生脑积水的一些症状不能逆转。To study learning deficits in congenitally hydrocephalic rats and prevantion by early shunt treatment. Normal rat（ n = 10）, hydrocephalic rats assessed hy drocephalic （ n = 9） and hydrocephalic rats shunt treated at 4 - 5 （ n = 8 ） or at 10 - 12 days of life （ n = 8 ）, the abilities of learning was tested using the morris water maze and open field , the data analyzed by one and two way AVONA and t -tests. NO significant between two trials, but performance was significantly different between the two shunt groups and not shunted congenitally hydrocephalic rats. Shunt treatment improved learning ability.

关 键 词：早期分流手术 脑积水 学习能力 大鼠 

分 类 号：R742.7[医药卫生—神经病学与精神病学]