谷胱甘肽转移酶M1基因多态性与大肠癌发生关系的多水平Meta回归分析  

Glutathione S-transferase Ml polymorphism and the risk on colorectal caner: a multilevel Meta regression

作　　者：何寒青[1] 陈坤[1] 张扬[1] 童峰[1] 范春红[1] 宋亮[1] 

机构地区：[1]浙江大学医学院流行病学与卫生统计学教研室,杭州310031

出　　处：《中华流行病学杂志》2005年第12期992-994,共3页Chinese Journal of Epidemiology

基　　金：国家自然科学基金(30471492)

摘　　要：目的 探讨谷胱甘肽转移酶(GST)M1基因多态性与大肠癌发生的关系及其影响因素。方法 采用多水平Meta回归分析方法进行合并效应值估计和异质性相关因素的研究。结果GSTM1基因多态性与大肠癌发生有关(合并OR值为1.17.95%CI：1.08～1.26)，种族类别、人群GSTM1基因基线缺失率等为研究间异质性的相关因素(P<0.05)；分层回归中，亚洲人、高加索人及低基线缺失水平人群(50%以下)中的GSTM1基因缺失型是大肠癌发生的危险因素(合并OR值分别为1.14、1.25、1.29)，结果具有统计学意义(P<0.05)。结论 GSTM1纯合缺失型是大肠癌发生的危险因素，并与人群的GSTM1基线缺失率和种族类别有关。Objective In order to investigate the relationship between Glutathione S-transferase M1 （GSTM1） status and the risk on colorectal cancer as well as to detect the related factors to this association. Methods A pooled analysis of multilevel Meta-regression was performed to estimate GSTM1 deficiency associated with the risks of colorectal cancer. Then subgroup Meta-regression was undertaken to evaluate the possible relationship between heterogeneity and the related characteristics. Results The overall pooled odds ratios of colorectal cancer risk associated with GSTM1 deficiency was 1.17 （95 % CI ： 1.08- 1.26 ）. Ethnicity, percent of GSTM1 deficiency in population had significant relationships with heterogeneity across the studies （P〈 0.05 ）. Results of subgroup Meta-regression showed that GSTM1 deficiency was significantly associated with colorectal cancer risk in ethnic subgroups of Asians, Caucasians and in low level （lower than 50 % ） of GSTM1 deficiency population（P〈 0.05 ）. The respective pooled ORs were 1.14, 1.25 and 1.29. Conclusion GSTM1 deficiency seemed to be a risk factor for colorectal cancer, while interactions on the characteristics of ethnicity, percentage of GSTM1 deficiency in the studied population were related to this association.

关 键 词：谷胱甘肽转移酶M1基因 基因多态性 大肠肿瘤 Meta回归分析 

分 类 号：R735.3[医药卫生—肿瘤]