非侵袭性与侵袭性泌乳素腺瘤细胞增殖活性的差异分析  

Proliferative difference between invasive and noninvasive prolactinimas

作　　者：钟晖东 佟小光[2] 

机构地区：[1]湛江市第二人民医院神经外科,广东湛江524003 [2]天津市环湖医院神经外科,天津300060

出　　处：《中国现代医学杂志》2005年第21期3233-3235,共3页China Journal of Modern Medicine

摘　　要：目的研究非侵袭性与侵袭性泌乳素(PRL)腺瘤细胞增殖活性的差异。方法检测28例泌素腺瘤中细胞核增殖抗原(PCNA)表达;用流式细胞仪(FCM)检测相应腺瘤中S期细胞比例,比较侵袭性泌乳素腺瘤与非乳素腺瘤PCNA表达与S期细胞比例的差异。结果非侵袭性腺瘤中PCNA表达的阳性指数为(37.1±10.33);侵袭性PRL腺瘤中PCNA表达的阳性指数为(76.7±11.18);两组比较,差别具有显著性(P<0.05);非侵袭性PRL腺瘤为(8.97±2.07)%,二组比较差异具有显著性(P<0.05);侵袭性PRL腺瘤S期细胞比例为(13.57±2.16)%。结论PCNA表达与S期细胞比例的检测结果是一致的,侵袭性与非侵袭性PRL腺瘤相比,细胞增殖能力较强,复发率高。[Objective] To evaluate the proliferative difference between invasive and non-invasive prolactinomas. [Methods] PCNA expression and the ratio of S phase cells were detected in 28 cases of prolactinomas, and the difference between invasive and non-invasive prolactinomas were compared. [Results] The PCNA positive index detected in invasive prolactinomas was （37.10±10.33） （P 〈0.05）; the ratio of S phase cells in invasive prolacinomas （13.57±2.16） % was also significantly different from non-invasive tumors （8.97±2.07%）. [ Conclusions] The proliferative ability of invasive PRL is strong and has high recurrence rate.

关 键 词：泌乳素腺瘤 PCNA S期细胞比例 

分 类 号：R739.41[医药卫生—肿瘤]