肝硬化患者食管静脉曲张的相关因素分析501例  

Correlative factors of esophageal varices in patients with hepatocirrhosis: an analysis of 501 cases

作　　者：崔春吉[1] 金永日[1] 朴熙绪[1] 裴风郁[1] 

机构地区：[1]延边大学医学院附属医院消化内科,吉林省延吉市133000

出　　处：《世界华人消化杂志》2005年第18期2269-2272,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨肝硬化患者食管静脉曲张(EV)的发生率及其危险因素.方法:对501例肝硬化患者的临床资料进行回顾性分析.结果:肝硬化患者EV的发生率在不同的性别(男性84.3%,284/337vs女性72.0%,164/118,P<0.05)、门静脉内径(≥14mm,85.9%,249/290vs<14mm,72.5%,153/211,P<0.05);及肝功能分级之间比较差异均有统计学意义,在有无嗜酒(嗜酒组84.9%,163/192vs非嗜酒组77.3%,239/309,P<0.05)、有无腹水(有腹水组83.9%,270/322vs无腹水组73.7%,132/179,P<0.05)之间比较差异亦均有统计学意义.肝硬化EV组血清白蛋白、胆碱酯酶显著低于非EV组,差异有统计学意义.性别及门静脉内径是肝硬化患者EV的的发病率明显相关(OR=0.491,P=0.016;OR=2.203,P=0.001)主要危险因素.结论:肝硬化患者EV与性别、门静脉内径、有无腹水、嗜酒、肝功能损害程度以及肝功能损害造成的血清白蛋白和胆碱酯酶代谢障碍等因素有一定关系,其中与性别及门静脉内径关系最密切.AIM： To investigate the incidence rate and the risk factors of esophageal varices （EV） in patients with hepatocirrhosis. METHODS： The clinical data of 501 patients with hepatocirrhosis were retrospectively studied. RESULTS： The incidence rate of EV in patients with hepatocirrhosis were significantly different between the groups of different sex （male 84.3% vs female 72.0%, P 〈0.05）, different diameters of the portal vein （≥14 mm 85.9% vs 〈14 mm 72.5%, P 〈0.05）, and different grades of Child-Pugh. It was significantly different between the patients with and without sotting （84,9% vs 77.3%, P 〈0.05） and ascites （83.9% vs 73.7%, P 〈0.05）. The serum albumin and cholinesterase in EV patients with hepatocirrhosis were significantly lower than those in non-EV patients. The EV incidence rate was correlated with the sex and diameters of portal vein （OR = 0.491, P = 0.016, OR = 2.203, P = 0.001）. CONCLUSION： The incidence of EV in patients with hepatocirrhosis is related to sex, the diameters of the portal vein, ascites, sorting, degree of hypohepatia, and dysbolism of serum albumin and cholinesterase. Sex and the diameters of the portal vein are more risky factors.

关 键 词：肝硬化 食管静脉曲张 发生率 

分 类 号：R575.2[医药卫生—消化系统] R571.305[医药卫生—内科学]