乳腺癌NF-κBHER2 VEGF-C与VEGFR3表达及其意义  

Expression of HER2, NF-КB, VEGF-C and VEGFR-3and Its Significance in Breast Cancer

作　　者：蔡春友[1] 付金瑞[1] 刘妍菊[1] 姚智[1] 

机构地区：[1]天津医科大学基础医学院免疫教研室,天津市300070

出　　处：《中国肿瘤临床》2005年第23期1333-1337,共5页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助(编号:30471962)

摘　　要：目的:探讨HER2、NF-kB、VEGF-C及其受体VEGFR-3在乳腺癌组织中的表达及相互关系。方法:应用免疫组化方法检测40例人乳腺癌组织和10例癌旁组织HER2、ER、NF-kB、VEGF-C及VEGFR-3的表达情况。结果:乳腺癌组织和癌旁组织NF-kB的阳性率分别为45.0%(18/40)和30.0%(3/10),差异无显著性(P>0.05),NF-kB与HER2蛋白的表达呈正相关(r=0.442,P=0.004)。Ⅲ级乳腺癌的NF-kB表达显著增强(P=0.018)。VEGF-C和VEGFR-3的表达显著增强,阳性率分别为70.0%(28/40)和57.5%(23/40),两者呈正相关(r=0.761);NF-kB和HER2与VEGF-C呈正相关(r值分别为0.373和0.342)。淋巴结转移组VEGF-C和VEGFR-3的阳性率分别等于90.0%和82.4%,明显高于无淋巴结转移组(56.5%和39.1%)。VEGFR-3阳性脉管数平均为8.44±2.58,明显高于无淋巴结转移组(5.12±3.75)。结论:NF-kB与HER2的表达为正相关,NF-kB和HER2蛋白与VEGF-C的表达呈正相关。Objective： To investigate the protein expression of nuclear transcription factor NF-KB, VEGF-C and its receptor VEGFR-3 in breast cancers, and the correlations among NF-KB, VEGF-C, VEGFR-3 and histological grading and nodal status. Methods： Forty samples of human breast cancer tissue and adjacent non-neoplastic breast tissue were examined for NF-KB, VEGF-C,VEGFR-3, as well as HER2 and ER by immunohistochemistry. Results： The expressions of NF-KB in breast cancer tissue and adjacent non-neoplastic breast tissue were 45.0%（18/40）and 30.0% （3/10, respectively. The expression of NF-KB in breast cancer has no significant difference compared to that in adjacent nonneoplastic breast tissue. NF-KB and HER2 expressions were positively correlated （r=0.442, P=0.004）. The expression of NF-KB in the group of grade 111 was increased compared to the other two groups （P=-0.018）. The positive rate of VEGF-C and VEGFR-3 in breast cancer were 70.0%（28/40）and 57.5%（23/ 40）respectively. The expression of VEGF-C and VEGFR-3 in breast cancer were increased in breast cancer （P〈0.05）, as compared with that in non-neoplastic breast tissue. The expression of VEGF-C correlated significantly with VEGFR3 （r=0.761）. Both NF-KB and HER2 were correlated with VEGF-C （r value were 0.373 and 0.342 respectively）. The positive rate of VEGF-C and of VEGFR-3 were 90.0% and 82.4% respectively in the lymph-node metastasis group, which was significantly higher thanthat of non-lymph node metastasis group （56.5% and 39.1% respectively）. The number of VEGFR-3 positive vessels in lymphnode metastasis group （8.44±2.58） was significantly higher compared to the nonlymph node metastasis group （5.12±3.75）. Conclusion： NF-KB is activated abnormally in part of the breast cancers. The expression of the NF-KB and of the HER2 protein positively correlate; both NF-KB and HER2 expression positively correlate with VEGF-C. HER2, NF-KB, VEGF-C and VEGFR-3 lies in a signaling pathway which promotes lymph node metastas

关 键 词：乳腺癌 细胞核因子ΚB 血管内皮细胞生长因子-C 血管内皮细胞生长因子受体-3 人类上皮细胞生长因子受体2 

分 类 号：R737.9[医药卫生—肿瘤]