免疫炎性因子在脑性瘫痪发病机制中的作用研究  

Role of proinflammatory cytokines in the pathogenesis of cerebral palsy

作　　者：孙杨[1] 文芳[2] 姚汉云[1] 肖玲[2] 程自立[2] 万均成[2] 

机构地区：[1]武汉大学人民医院神经内科,硕士研究生430060 [2]武汉大学人民医院神经精神病研究所,430060

出　　处：《卒中与神经疾病》2005年第6期359-361,共3页Stroke and Nervous Diseases

摘　　要：目的探讨免疫炎性因子在脑性瘫痪(脑瘫)发病机制中的作用。方法运用双抗体夹心ABC-ELISA法检测31名脑瘫患儿和20名健康儿童及37名脑瘫高危因素新生儿(新生儿病例组)和20名正常新生儿的血清TNF-α和IL-6水平。结果脑瘫患儿血清TNF-α和IL-6水平均明显高于脑瘫对照组(P<0.05),新生儿病例组血清TNF-α和IL-6水平明显高于新生儿病例对照组(P<0.05);脑瘫组和新生儿病例组间TNF-α水平有统计学差异(P<0.05),前者较高,而2组间的IL-6水平无显著差异(P>0.05)。结论免疫炎性因子的过度表达在脑瘫的发病过程中发挥了重要作用,高水平的免疫炎性因子可能是脑瘫发病的一个独立危险因素。Objective To investigate the role of proinflammatory cytokines in the mechanisms of cerebral palsy. Methods Thirty-one patients diagnosed as cerebral palsy, twenty healthy controls and neonates （n = 37） who suffered hypoxic-ischemic injury and/or perinatal infection, and twenty healthy neonates who were used as controls were studied retrospectively. Enzyme-linked immunosorbent assays （ELISA） was performed for TNF-α and IL-6 in serum from all subjects. Results TNF-αand IL-6 were significantly higher in cerebral palsy patients than those in controls （P〈0. 05） , TNF-α and IL-6 were significantly higher in suffered neonates than in controls （P〈0. 05） ;TNi-α is significantly higher in patients than in suffered neonates （P〉0. 05）, there was no statistical difference of IL-6 levels between two groups. Conclusions Overexpressed proinflammatory cytokines plays an important role in the pathogenesis of cerebral palsy and may be used as an independent risk factor of cerebral palsy.

关 键 词：脑瘫 免疫炎性因子 免疫-神经-内分泌网络 IL-6 TNF-Α 

分 类 号：R742[医药卫生—神经病学与精神病学]