Investigation of Calcitonin and Calcitonin Gene-related Peptide in 88 Cases of Medullary Thyroid Carcinoma  

甲状腺髓样癌降钙素及其基因相关肽检测的临床意义——附88例报告(英文)

作　　者：于洋[1] 高明[1] 李树玲[1] 徐本义[1] 孙保存[1] 刘经组[1] 

机构地区：[1]天津医科大学附属肿瘤医院头颈科,300060

出　　处：《The Chinese-German Journal of Clinical Oncology》2005年第6期344-346,共3页中德临床肿瘤学杂志（英文版）

基　　金：This project was supported by a grant from the Natural Science Foundation from Tianjin Government.

摘　　要：Objective： To investigate the changes of calcitonin （CT） and calcitonin gene-related peptide （CGRP） in patients with medullary thyroid carcinoma （MTC）. Methods： Fifty-eight cases of MTC were selected and the relationship between the CT levels and metastasis was investigated. The immunohistochemical method was used to detect the expression of CT and CGRP in the 58 samples of MTC tissues. The CT and CGRP in 30 newly diagnosed MTC inpatients were measured before operation and in the first few days after operation using a radioimmunoassy. Results： （1） The rate of residual tumor had a significant difference between the normal serum CT group one month after operation and the elevated group at the same period （P〈0.01）. （2） Immunohistochemical study revealed the positive rate of CT was about 98%, and that of the CGRP was 87.8%. （3） Part of the patients had an elevated CGRP levels while CT levels was normal. （4） The serum CT levels were decreased to a stable range one week after operation. Conclusion： CT is a useful index to evaluate the efficacy of surgical treatment. The measurement of serum CGRP is helpful in the diagnosis of MTC, especially for those whose preoperative CT levels are normal.

关 键 词：CALCITONIN calcitonin gene-related peptide medullary thyroid carcinoma 

分 类 号：R736.1[医药卫生—肿瘤]