酸敏感离子通道的研究进展  

Growing insights into acid-sensing ion channels

作　　者：张政[1] 蔡炳祥[1] 关永源[1] 

机构地区：[1]中山大学中山医学院药理学教研室,广东广州510080

出　　处：《中国药理学通报》2005年第12期1414-1417,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30271503)

摘　　要：酸敏感通道广泛表达于中枢与外周神经系统,在疼痛、伤害感觉中发挥了重要的作用。其分子结构与分布特点、调控机制以及在某些病理生理过程中的作用已经得到了部分阐明。未来对其研究将是离子通道研究领域的热门课题。Acid-sensing ion biquitously expressed both channels （ ASICs ） are uin periphery nervous system, where they are involved in nociception, mechanosensation, inflammation , cardiac angina, and in central nervous system, where they are essential to a variety of physiologic and pathophysiologic processes, such as synaptic plasticity , learning , memory and ischemic brain injury. Here in the article, we present a collection of key points about ASICs, ranging from molecular identity and expression, regulatory mechanisms responsible for channel gating to their multiple functions. Finally, a future prospect for the investigation of ASICs is outlined.

关 键 词：酸敏感通道 痛觉 伤害感觉 缺血 

分 类 号：R-05[医药卫生] R322.81