High mechanical index post-contrast ultrasonography improves tissue structural display of hepatocellular carcinoma  

作　　者：CHEN Min-hua YANG Wei DAI Ying WU Wei 

机构地区：[1]Department of Ultrasound, Peking University School of Oncology,Beijing 100036, China

出　　处：《Chinese Medical Journal》2005年第24期2046-2051,共6页中华医学杂志（英文版）

基　　金：This study was supported by the special incubation funds of majorresearch plan of Beijing Municiple Science & TechnologyCommission ( No. Z0005190040431 ) and a grant from theFoundation of Capital Medical Development (No.ZD 199909)

摘　　要：Background The advent of second generation agent-SonoVue and low mechanical index real-time contrast enhanced ultrasonography （CEUS） imaging have been shown to improve the diagnostic performance of uhrasonography in hepatocellular carcinoma （HCC）. But no report has described the effect of high mechanical index （MI） post-CEUS. This study aimed to investigate the value of post-CEUS in displaying tissue structures of HCC. Methods Seventy-six HCCs in 65 patients were included in the study. Each patient underwent three scans, high-MI （ MI ： 0. 15 - 1.6 ） pre-contrast ultrasound, low-MI （ MI ： 0. 04 - 0. 08 ） CEUS with contrast agent SonoVue, and high-MI post-contrast ultrasound, which was performed within 3 minutes after CEUS. The size, boundary, echogenicity, internal echotexture and posterior acoustic enhancement of the HCCs in the conventional scans before and after CEUS were evaluated. According to pathological evidence, diagnosis rates of pre-contrast, CEUS and post-contrast scans were determined and compared. The potential mechanism of post-contrast ultrasound imaging was also discussed. Results Compared with pre-contrast, post-contrast ultrasound showed improvement in image quality in most HCCs： twenty-six （34. 2% ） more lesions showed well defined margins and fourteen （18.4%） more nodules showed halo sign; twenty-three （30. 3% ） lesions demonstrated enlarged in sizes; changes in echogenicity were seen in 30 lesions （39.5%） ; eighteen （23.7%） more lesions showed heterogenecity and 20 （26. 3% ） more lesions showed “mosaic”or “nodule-in-nodule” sign; twelve （15.8%） more lesions showed posterior acoustic enhancement. Post-contrast ultrasound showed increased diagnostic accuracy of 93.4% （71/76）, compare with 88.2% （67/76） of CEUS alone. Conclusions High-MI post-contrast ultrasound utilizes harmonic signals during the rupture of microbubbles, and significantly improves the display of echo-characteristics of HCCs in ultrasound images, which adds dBackground The advent of second generation agent-SonoVue and low mechanical index real-time contrast enhanced ultrasonography （CEUS） imaging have been shown to improve the diagnostic performance of uhrasonography in hepatocellular carcinoma （HCC）. But no report has described the effect of high mechanical index （MI） post-CEUS. This study aimed to investigate the value of post-CEUS in displaying tissue structures of HCC. Methods Seventy-six HCCs in 65 patients were included in the study. Each patient underwent three scans, high-MI （ MI ： 0. 15 - 1.6 ） pre-contrast ultrasound, low-MI （ MI ： 0. 04 - 0. 08 ） CEUS with contrast agent SonoVue, and high-MI post-contrast ultrasound, which was performed within 3 minutes after CEUS. The size, boundary, echogenicity, internal echotexture and posterior acoustic enhancement of the HCCs in the conventional scans before and after CEUS were evaluated. According to pathological evidence, diagnosis rates of pre-contrast, CEUS and post-contrast scans were determined and compared. The potential mechanism of post-contrast ultrasound imaging was also discussed. Results Compared with pre-contrast, post-contrast ultrasound showed improvement in image quality in most HCCs： twenty-six （34. 2% ） more lesions showed well defined margins and fourteen （18.4%） more nodules showed halo sign; twenty-three （30. 3% ） lesions demonstrated enlarged in sizes; changes in echogenicity were seen in 30 lesions （39.5%） ; eighteen （23.7%） more lesions showed heterogenecity and 20 （26. 3% ） more lesions showed “mosaic”or “nodule-in-nodule” sign; twelve （15.8%） more lesions showed posterior acoustic enhancement. Post-contrast ultrasound showed increased diagnostic accuracy of 93.4% （71/76）, compare with 88.2% （67/76） of CEUS alone. Conclusions High-MI post-contrast ultrasound utilizes harmonic signals during the rupture of microbubbles, and significantly improves the display of echo-characteristics of HCCs in ultrasound images, which adds d

关 键 词：ultrasonography contrast enhanced ultrasound liver neoplasm tissue structure 

分 类 号：R735.7[医药卫生—肿瘤]