Mlüler细胞与视网膜神经元的关系  

Relation between Müller cells and retinal neurons

作　　者：何宇[1] 谢学军[2] 

机构地区：[1]四川大学华西医院西藏成办分院眼科,四川省成都市610042 [2]成都中医药大学眼科,四川省成都市610075

出　　处：《眼科新进展》2005年第6期566-568,共3页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:30572407)

摘　　要：Müller细胞是脊椎动物视网膜中最重要的胶质细胞,它贯穿视网膜全层,与视网膜三级神经元共同构成致密的“神经-胶质”网。近年来,随着对Müller细胞功能研究的深入,逐渐发现它在视网膜神经元的发育、营养、代谢中均发挥着重要作用。它诱导神经元在发育中的迁移、分化,参与神经元能量供应,并通过控制视网膜神经元的微环境和释放神经活性物质而主动调制神经元活动,此外,还以谷氨酸代谢和神经营养因子的分泌等形式保护神经元免受各种病理损害。Mǔller cell in vertabrates cells are the most principal glia retina. They cross the entire thickness of retina,and form a compact“neuron-glial” net with the three-order retinal neurons. With the deeper research in Mǔller cells, it was gradually found that they exert important influence on the development, nutrition and metabolism of retinal neurons. They induce neuronal movement and differentiation in the course of retinal development, supply energy for neurons, and modulate neuronal activity by controlling neuronal microentironment or releasing neuroactive substances. In addition, they protect retinal neurons from pathological damage by metabo- lizing glutamate and secreting neurotrophic factors.

关 键 词：Mǔller细胞 视网膜神经元 

分 类 号：R774[医药卫生—眼科]