屏氧酶-1基因多态性和脑梗死的相关性研究  

Relationship between polymorphism of paraoxonase gene and cerebral infarction

作　　者：肖志杰[1] 赵水平[2] 聂赛[2] 谭利民[1] 蒋波[1] 吴军[1] 周宏年[2] 张贺[1] 

机构地区：[1]中南大学湘雅二医院神经内科,长沙410011 [2]中南大学湘雅二医院心内科,长沙410011

出　　处：《临床神经病学杂志》2005年第6期418-421,共4页Journal of Clinical Neurology

摘　　要：目的探讨屏氧酶1(PON1)基因192位GlnArg(Q/R192)多态性与脑梗死的关系。方法采用聚合酶链式反应(PCR)限制性片段长度多态性方法测定375例脑梗死患者(脑梗死组)和339名健康普查者及非心脑血管疾病患者(对照组)的PON1Q/R192基因多态性,进行基因型分析;并对各基因型与血脂水平关系进行比较。结果在研究的总人群中,PON1Q/R1923种基因型频率分别为QQ13.6%、Q44.0%、RR42.4%;PON1Q/R192基因型和等位基因频率分布在脑梗死组与对照组之间差异无显著性(P>0.05);各基因型之间血脂水平差异无显著性(P>0.05)。结论未发现PON1Q/R192基因多态性与脑梗死存在相关关系。Objective To investigate the correlation between polymorphism of gene paraoxonase Gln-Arg 192 （PON-1 Q/R 192） and cerebral infarction （CI）. Methods The polymorphisms of gene PON-1 Q/R 192 from 375 patients with CI and 339 persons without cardiovascular or cerebrovascular diseases were detected by polymerase chain reaction-restricted fragments length polymorphism method. All the genotypes were analyzed and the correlation with blood lipids was evaluated. Results The PON-1 Q/R 192 genotype distribution in the all subjects studied was 13.6% of QQ, 44. 0% of QR and 42.4% of RR, respectively. There was no significant difference in PON-1 Q/R 192 allele and genotype distribution between CI group and control group （P 〉 0.05 ）. No significant association between Q/R 192 genotype and blood lipids was found. Conclusion The polymorphism of PON-1 Q/R 192 gene is not associated with CI.

关 键 词：屏氧酶-1 基因多念忡 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]