肝硬化大鼠胃窦Cajal间质细胞的变化  

The changes of interstitial cell of Cajal in antrum of rats with liver cirrhosis

作　　者：朱金照[1] 许其增[1] 刘庆宏[1] 

机构地区：[1]南京军区福州总医院消化内科,福州350025

出　　处：《胃肠病学和肝病学杂志》2005年第6期618-620,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的观察肝硬化大鼠胃窦Cajal间质细胞的变化,探讨肝硬化胃肠动力障碍的相关机制。方法20只Wister大鼠随机分为肝硬化模型组和对照组,采用四氯化碳溶剂大腿根部皮下注射法制作肝硬化模型,免疫组化染色观察胃窦C-kit阳性Cajal间质细胞的变化,并用透射电镜观察胃窦Cajal间质细胞的超微结构改变。结果与对照组比较,肝硬化组大鼠胃窦C-kit阳性Cajal间质细胞明显减少(P<0.01),透射电镜观察显示Cajal间质细胞与其他细胞间连接减少,线粒体肿胀、细胞器减少,胞浆内空泡形成。结论肝硬化大鼠胃窦Cajal间质细胞发生明显变化,Cajal间质细胞减少及其超微结构改变可能与肝硬化大鼠胃动力障碍有关。Objective To observe the changes of interstitial cell of Cajal（ICC） in antrum of rats with liver cirrhosis. Methods Twenty wister rats were randomly divided into control group and cirrhosis model group, and model group rats were given the CCl4 to induce liver cirrhosis. Immunohistochemi cal staining was used to detected the content of C - kit positive ICC in antrum of rats, meanwhile the uhrastructure of ICC were observed by electron microscope. Results Comparing with control group, the content of C - kit positive ICC of antrum in model group was markedly decreased （ P 〈 0.01 ）. The junctions between ICC and other cells were decreased, and mitocnondria swelled, vacuoles formed were ebserved in ICC. Conclusion The markedly changes of ICC in antrum may be associated with the delay of gastric emptying.

关 键 词：肝硬化 胃动力 CAJAL间质细胞 

分 类 号：R574.4[医药卫生—消化系统]