伽玛刀治疗脑胶质瘤的临床分析(附142例临床报道)  

The clinical report of gamma knife radiosurgery for cerebral glioma(Report of 142 cases)

作　　者：邓印辉[1] 何咏[1] 梁舜尧[1] 黄敏仪[1] 李凯[1] 

机构地区：[1]广州医学院第二附属医院神经外科

出　　处：《立体定向和功能性神经外科杂志》2005年第6期329-331,共3页Chinese Journal of Stereotactic and Functional Neurosurgery

摘　　要：目的评价伽玛刀对脑胶质瘤的治疗效果。方法自1993年12月至2003年12月经伽玛刀治疗且有完整随访资料的脑胶质瘤病例142例,其中男性88例,女性54例,年龄12～78岁(平均37.5±9.4岁),周边剂量10～22Gy(平均15.3Gy)。结果142例随访3～106个月(平均17.7个月),65例低恶度胶质瘤影像复查结果:消失11例(17%),缩小25%以上27例(42%),无变化15例(23%),恶化12例(18%),有效率为82%。77例高恶度胶质瘤影像复查,近期及远期有效率分别为80%和57%,6、12、24和36个月生存率分别为94.8%,84.4%,50.6%和32.5%。43例(30.3%)患者于治疗后出现放射性水肿。结论伽玛刀治疗脑胶质瘤,可提高患者生存质量,延长生命。对体积较小的低恶度胶质瘤,其疗效明确;对高恶度脑胶质瘤,可控制肿瘤的生长,但易复发。Objective To investigate the clinical effects of gamma knife radiosugery on cerebral gliomas. Methods From Dec. 1993 to Dec. 2003,142 cases of glioma were treaded with gamma knife, there were 88 males and 54 females. Their age ranged from 12 to 78 years （37.5±9.4）, the marginal dose of the target were 10-22Gy （averaged 15.3Gy）. Results Patients had been followed up from 3 to 106 months （averaged 17.7 months）. The imaging examination in low grade gliomas showed disappeared in 11 cases （17%）,reduced more than 25% in 27 （42%）,unchanged in 15 cases （23%） and the 12 cases （ 18 % ） became worse. The effective rate was 82 %. In high grade gliomas, the effective rates in imaging examination in timed and long timed follow up were 80 % and 57 % ,respectively. The survival rates in 6,12,24 and 36 months were 94.8 % ,84.4 %, 50.6 % and 32.5 % respectively. The radioactive brain edema was found in 43 patients （30.3 %） after treatment. Conclusion The effectiveness of glioma treated by gamma knife is definite, the survival quality of patients was improved and their life is prolonged.

关 键 词：伽玛刀 胶质瘤 立体定向放射外科 

分 类 号：R739.41[医药卫生—肿瘤]