一阶导数分光光度法测定几种制剂中氟罗沙星  

Determination of fleroxacin in its preparations by the first derivative spectrophotometry

作　　者：张素斌[1] 梁巧荣[1] 赵慧春[2] 

机构地区：[1]肇庆学院轻工化学系,广东肇庆526061 [2]北京师范大学化学系,北京100875

出　　处：《应用化工》2005年第12期776-777,784,共3页Applied Chemical Industry

摘　　要：用一阶导数分光光度法测定了氟罗沙星片剂、胶囊和粉针剂中氟罗沙星的含量.氟罗沙星的线性范围为0.4～20.0 μg/mL,线性相关系数为0.9998,检出限为0.04μg/mL,对12μg/mL的氟罗沙星溶液测定10次的相对标准偏差为1.4%,回收率为98%～105%.该法简便、快速、准确,测定三种样品的结果令人满意.A first derivative spectrophotometric method is presented for the determination of fleroxacin （FLX） in tablets, capsules and powder for rejection. The linear range of the determination is 0.4 - 20.0 μg/mL for FLX with r = 0.9998, the detection limit is 0. 04 /μg/mL, the relative standard deviation for the determination of 12 μg/mL FLX is 1.4% （n = 10）. The recoveries are in the range of 98% -105%. The method is simple, rapid and accurate, and the analytical result is satisfactory.

关 键 词：氟罗沙星 片剂 胶囊 粉针剂 一阶导数分光光度法 

分 类 号：O657.32[理学—分析化学] R927.2[理学—化学]