运动性疲劳对大鼠海马一氧化氮合成酶活性的影响  

Research on Effects of Exercise-induced Fatigue on Activity of Nitric Oxide Synthase(NOS) in Rat hippocampus

作　　者：曹电康[1] 刘鸿宇[1] 续俊[1] 姚晋宏[1] 白莉芳[1] 

机构地区：[1]中北大学运动人体科学实验中心,山西太原030051

出　　处：《北京体育大学学报》2005年第12期1647-1648,共2页Journal of Beijing Sport University

基　　金：中北大学科学基金(2004)资助

摘　　要：为了探讨海马一氧化氮合成酶(NOS)与运动性疲劳的关系,研究了运动性疲劳对大鼠海马NOS活性的影响。经4周大强度游泳训练制成大鼠运动疲劳模型,在安静状态下,用放射免疫学方法检侧了大鼠海马NOS总活性。结果表明:疲劳组大鼠海马NOS总活性大于对照组(P<0.05)。说明:运动性疲劳作为一种应激可使大鼠海马神经元中的NOS上调,海马NOS神经元参与了中枢运动性疲劳的形成,其机理可能与海马神经元对应激反应的心理、行为、内分泌调节以及NO的神经毒性有关。In order to explore the relationship between exercise-induced fatigue and nitric oxide synthase （NOS） in hippocampus, dais study explored effects of exercise-induced fatigue on expression of NOS in rat hippocampus. After four-week swimming exercise with high-level imensity, under the quiet situation, the general NOS activity in rat hippocampus was tested adopted radioimmunological technique. The results of this study indicated that there existed a significant increase of the general NOS activity in rat hippocampus in fatigue group （ P 〈 0. 05 ）. It was concluded that exercise-induced fatigue as a stress can inspire upregulated expression of NOS in hippocampus, which was involved in forming of exercise-induced central fatigue. It was proposed that it was due to the psychological, behavioral, endocrine regulation of hippocampus on stress, and NO neurotoxicity.

关 键 词：运动性疲劳 海马 一氧化氮合成酶(NOS) 大鼠 

分 类 号：G804.2[文化科学—运动人体科学]