乳腺癌组织中雌激素受体与C-erbB-2基因、多药耐药基因MDR1表达  

EXPRESSION OF C-erbB-2 GENE,MULTIDRUG-RESISTANCE GENE(P-gp) ANG THEIR INTERRELATIONSHIP TO ER IN HUMAN BREAST CANCER

作　　者：冯继锋[1] 吴剑秋[1] 尹必俭[1] 庄民[2] 

机构地区：[1]江苏省肿瘤防治研究所江苏省肿瘤医院内科,江苏南京210009 [2]徐州医学院附属连云港医院肿瘤内科,江苏连云港222002

出　　处：《实用临床医药杂志》2005年第11期8-11,15,共5页Journal of Clinical Medicine in Practice

基　　金：江苏省卫生厅科技基金资助项目(H200141)

摘　　要：目的观察乳腺癌组织中雌激素受体(ER)与C-erbB-2基因、多药耐药基因MDR1(P-gp)蛋白表达并探讨其相互关系。方法用免疫组织化学法(S-P法)对162例乳腺癌手术切除标本进行ER、C-erbB-2、MDR1(P-gp)检测,结果作统计学分析。结果ER、C-erbB-2、MDR1(P-gp)的阳性表达率各为53.7%、37.0%和27.7%。ER在分化越高和无腋窝淋巴结转移者的乳腺癌中其阳性表达率高,C-erbB-2在分化越差的乳腺癌中其阳性表达率高,组间相比有显著差异(P<0.05)。在有腋窝淋巴结转移的乳腺癌中C-erbB-2、MDR1(P-gp)表达率明显升高。C-erbB-2与MDR1(P-gp)的阳性表达率间具有一定的正相关性,C-erbB-2表达与ER表达呈负相关。结论ER、C-erbB-2基因、MDR1(P-gp)在乳腺癌中有一定的内在联系,联合检测有助于乳腺癌预后的判断,为合理制定综合治疗方案提供依据。Objective To observe the protein expression of C-erbB-2 gene and multidrug resistance genel/P-glycoprotein （MDR1/P-gp） in human breast cancer and to explore their interrelationships to estrogen receptors （ER）. Methods ER, C-erbB-2 protein and MDRI（P-gp） were detected in formalin2fixed, paraffin embedded tissues from 162 postoperative patients with breast cancer by immunohistochemical stain （SP）. During this period, they were not treated by chemotherapy. Results of detection were analyzed statistically. Results Positive rate of ER, C-erbB-2 protein and MDR1/P-gp expression were 53.7%, 37.0% and 27.7%, respectively. The positive rate of ER expression was higher in well differentiated and axillary lymph node negative breast cancer. The positive rate of C-erbB-2 expression was higher in poor differentiated breast cancer（P 〈 0.05）. The positive rate of C-erbB-2 and MDR1 （P-gp）expression was significantly higher in axillary lymph node positive breast cancer. The positive rate of C-erbB-2 expression was correlate with that of MDRI（P-gp）, while correlate inversely with that of ER in human breast cancer. Conclusion Cer tain degree of interrelationship exists among ER , C - erbB - 2 gene and MDR 1 （ P - gp ） in human breast cancer . Combined detection might be useful for the estimate of prognosis and the establishment of synthetical therapy regimen in breast cancer.

关 键 词：乳腺癌 雌激素受体 C-ERBB-2基因 多药耐药基因MDR1 基因表达 

分 类 号：R737.9[医药卫生—肿瘤] R969[医药卫生—临床医学]