两亲性聚(L-谷氨酸γ-苄基酯)-聚乙二醇接枝共聚物的自组装行为和载药性能研究  

STUDIES OF SELF-ASSEMBLY BEHAVIOR AND DRUG-LOADING PROPERTIES FOR AMPHIPHILIC POLY(γ-BENZYL L-GLUTAMATE) POLY(ETHYLENE GLYCOL)GRAFT COPOLYMERS

作　　者：章苏宁[1] 陈涛[1] 林嘉平[1] 董秀斌[1] 林绍梁[1] 

机构地区：[1]华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室,上海200237

出　　处：《高分子学报》2005年第6期929-932,共4页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号50273011);上海市曙光计划(项目号02SG025);上海市科委纳米专项基金(基金号0352nm109)资助项目

摘　　要：Self-association behavior of an amphiphilic polypeptide graft copolymer,poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol), and the drug carrier capability of the formed micelles were examined by fluorescence spectroscopy,transmission electron microscopy and UV spectroscopy.It was found that the hydrophobic inner core of the micelles formed by poly(γbenzyl L-glutamate)(PBLG) segments can act as an incorporation site for hydrophobic drugs.The drug-loading content of the graft copolymer micelles tends to be larger when the content of the PBLG segments in the copolymer increases.The results obtained from the drug-release studies showed that the drug-release rates were dependent on the chemical nature of the graft copolymer.Self-association behavior of an amphiphilic polypeptide graft copolymer, poly（ γ-benzyl L-glutamate）-g- poly（ethylene glycol）, and the drug carrier capability of the formed micelles were examined by fluorescence spectroscopy, transmission electron microscopy and UV spectroscopy. It was found that the hydrophobic inner core of the micelles formed by poly （ γ-benzyl L-glutamate ） （ PBLG ） segments can act as an incorporation site for hydrophobic drugs. The drug-loading content of the graft copolymer micelles tends to be larger when the content of the PBLG segments in the copolymer increases. The results obtained from the drug-release studies showed that the drug-release rates were dependent on the chemical nature of the graft copolymer.

关 键 词：聚(L-谷氨酸γ-苄基酯) 自组装 药物载体 分子链构象 

分 类 号：TQ460.1[化学工程—制药化工]