实验性牙移动过程中三叉神经节内神经生长因子受体TrkA的改变  

Changes of NGF receptor TrkA in trigeminal ganglion during experimental tooth movement in rats

作　　者：徐娟[1] 刘洪臣[1] 袁维秀[2] 黄旭明[1] 

机构地区：[1]解放军总医院口腔科,北京1000853 [2]解放军总医院麻醉科,北京1000853

出　　处：《口腔医学》2005年第6期335-336,共2页Stomatology

基　　金：国家自然科学基金资助项目(C03031103);全军医药卫生科研基金资助项目(02M013)

摘　　要：目的观察实验性牙移动时,神经生长因子受体TrkA在三叉神经节内的改变。方法采用免疫荧光方法观察大鼠实验性牙移动后,三叉神经节内TrkA免疫阳性细胞的改变。结果实验性牙移动加力24 h组3、d组、1周组,实验侧三叉神经节内TrkA免疫阳性神经元较对侧增多;2周组实验侧三叉神经节TrkA免疫阳性神经元与对照组相比差异无显著性。结论实验性牙移动时,实验侧三叉神经节内TrkA免疫阳性神经元增多。Objective To observe the changes of TrkA-inununoreactive neurons in trigeminal ganglion （TG） during the experimental tooth movement. Methods hnmunoiluorcsenee histochemical was used to qualitively examine the distribution of TrkA-immunoreaetive neurons in the TG during the experimental tooth movement. Results Compared with the control side, the number of TrkA-ir neurons increased in TG within 24 hours after the experimental tooth movement and remained elevated for 3 days. In the 2-week group, the expression of TrkA by TG neurons returned to control level. Conclusion The number of TrkA-immunoreactive neurons increases in TG during experimental tooth movement.

关 键 词：实验性牙移动 神经生长因子受体 大鼠 三叉神经节 TRKA 

分 类 号：R783.5[医药卫生—口腔医学]