碱性成纤维细胞生长因子、转化生长因子-β_1及其受体表达与结直肠癌临床病理特征的关系  

Expression of Basic Fibroblast Growth Factor, Transforning Growth Factor β_1, its Receptor and Their Relationships to Clinicopathological Characteristics of Colorectal Cancer

作　　者：孙秀威[1] 冯占军[2] 陈飞[1] 隋红[1] 白玉贤[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院内科,150040 [2]哈尔滨医科大学附属肿瘤医院病理科,150040

出　　处：《胃肠病学》2005年第6期336-338,共3页Chinese Journal of Gastroenterology

基　　金：黑龙江省攻关课题项目(No.GB02C146-02)资助

摘　　要：背景:血管生成是肿瘤生长、侵袭和转移的关键步骤,其过程受多种血管生成因子调控目的:研究血管生成因子碱性成纤维细胞生长因子(bFGF)、转化生长因子(TGF)-β_1及其受体TβRⅠ在结直肠癌中的表达和意义。方法:应用免疫组化方法检测60例结直肠癌组织中bFGF、TGF-β_1和TβRⅠ的表达,并与20例正常结直肠黏膜进行比较,分析三者的表达与结直肠癌临床病理特征的关系。结果:结直肠癌组织中bFGF、TGF-β_1和TβRⅠ表达阳性率增高,与正常结直肠黏膜比较有显著差异(P<0.05);且三者的表达与肿瘤Dukes分期、浸润深度和淋巴结转移有关(P<0.05)结论:bFGF、TGF-β_1和TβRⅠ在结直肠癌的发生、发展和转移中起重要作用,可作为判断结直肠癌生物学行为的重要指标。Background： Angiogenesis is the key process of tumor development, invasiveness and metastasis, and is affected by many modulating factors. Aims： To investigate the expression and significance of basic fibroblast growth factor （bFGF）, transforming growth factor （TGF）-β1 and its receptor TβR I in colorectal cancer. Methods： The expression of bFGF, TGF-β1 and TβR Ⅰ was evaluated by immunohistochemical method in 60 cases of colorectal cancer tissues. The correlations between their expression and the clinicopathological characteristics of cancers were analyzed. Twenty normal colorectal mucosa specimens served as controls. Results： The expression rates of bFGF, TGF-β1 and TβR Ⅰ in colorectal cancer tissues were significantly increased than those in the normal colorectal mucosa （P〈0.05）, and were closely correlated with Dukes staging, infiltrating depth and lymphatic metastasis （P〈0.05）. Conclusions： bFGF, TGF-β1 and TβR Ⅰ may play important roles in carcinogenesis, progression and metastasis of eoloreetal cancer, which might be promising markers for predicting the biological behavior of colorectal cancer.

关 键 词：结直肠肿瘤 碱性成纤维细胞生长斟子 转化生长因子Β 受体 转化生长因子β 血管生成 

分 类 号：R735.3[医药卫生—肿瘤]