几丁糖在兔角膜碱烧伤中的抗氧化损伤作用  

Role of chitosan in preventing lipid peroxidation damage following corneal alkali burn

作　　者：向艳[1] 杨红[1] 王蓉[1] 张晓农[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院眼科,武汉430030

出　　处：《中华创伤杂志》2006年第1期36-39,共4页Chinese Journal of Trauma

基　　金：湖北省卫生厅科技计划资助项目(Lj200102)

摘　　要：目的探讨20g/L医用几丁糖在角膜碱烧伤中对脂质过氧化损伤、炎症反应的影响。方法以15只新西兰大白兔制作兔角膜碱烧伤模型,设立几丁糖治疗组(右眼)和对照组(左眼)。于烧伤后第7,14,28天各取两组5只兔的角膜和房水检测超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量,并观察角膜组织病理学变化。结果医用几丁糖治疗组较对照组同期SOD活性高,MDA生成量少,角膜炎症反应轻。结论几丁糖在角膜碱烧伤急性期治疗中具有较强的抗脂质过氧化损伤、抑制炎症及促进愈合的作用。Objective To understand the effects of chitosan at 20 g/L on lipid peroxidation damage and inflammation reaction at the early stage after corneal alkali burn. Methods Corneal alkali burn model was made in 15 New Zealand white rabbits that were divided into chitosan treatment group （fight eyes） and control group （left eyes）. At days 7, 14 and 28 respectively after burn, five rabbits were killed each time for detecting the activity of superoxide dismutase （SOD） and the content of malondialdehyde （ MDA ） in the corneal and aqueous humor and for microscopically observing histopathological changes of the corneal. Results Compared with control group, the cornea epithelium was healed faster, with less inflammatory reaction, higher activity of SOD and lower content of MDA in chitosan group. Conclusion Chitosan plays an important role in preventing lipid peroxidation damage, inhibiting inflammatory infiltration and promoting corneal epithelial healing.

关 键 词：壳多糖 眼烧伤 碱类 脂质过氧化 

分 类 号：R779.1[医药卫生—眼科]