散血明目片对兔tPVR玻璃体中生长因子和细胞间粘附分子浓度的影响  

Study on effect of SanXueMingMu tablet for growth factors and intercellular adhesion molecule in hyaloid body during traumatic proliferative vitreoretinopathy in rabbits

作　　者：魏为[1] 彭清华[1] 唐罗生[1] 韩琦[1] 

机构地区：[1]中南大学湘雅二医院眼科,湖南省长沙市410011

出　　处：《眼科新进展》2006年第1期7-11,共5页Recent Advances in Ophthalmology

基　　金：湖南省自然科学基金项目(编号:02JJY2035);湖南省科技厅科研基金项目(编号:02SSY3096)~~

摘　　要：目的探讨活血利水之散血明目片对外伤性增生性玻璃体视网膜病变(traumaticproliferativevitreoretinopathy,tPVR)玻璃体中碱性成纤维细胞生长因子(basicfibroblastsgrowthfactors,bFGF)、表皮生长因子(epidermalgrowthfactor,EGF)和细胞间粘附分子1(intercellularadhesionmolecule1,ICAM1)浓度的影响及防治PVR的作用机理。方法50只家兔随机抽取40只,造成外伤性PVR模型,随机分成散血明目片组、桃红四物汤组、猪苓散组、模型组,另10只为空白组。连续灌胃1月后,检测玻璃体中bFGF、EGF和ICAM1的含量,检眼镜眼底检查并取眼球壁标本作组织病理学观察。结果散血明目片组玻璃体中bFGF、EGF、ICAM1含量低于模型组,2者有显著性差异(P<0.01),散血明目片组EGF含量与空白组比较差异无显著性(P>0.05),bFGF含量高于空白组(P<0.05),桃红四物汤组与猪苓散组bFGF、EGF、ICAM1浓度均低于模型组,且均高于空白组,有显著性差异(P<0.01),桃红四物汤组与猪苓散组bFGF、EGF、ICAM1浓度高于散血明目片组,有显著差异(P<0.01)。各治疗组ICAM1含量高于空白组,有显著性差异(P<0.01)。结论活血利水之散血明目片有可能通过降低玻璃体中bFGF、EGF和ICAM1的浓度,抑制增殖细胞的过度增生从而防治PVR形成和发展。Objective To study the curative and preventive effects of SanXueMingMu tablet on traumatic proliferative vitreoretinopathy （tPVR） in rabbits. Methods Forty rabbits were selected randomly from 50 rabbits and induced to tPVR models, then divided into four groups： the first group was treated with SanXueMingMu tablet, the second with TaoHongSiWuTang, the third with ZhuLingSan and the model group. The rest 10 rabbits were set as the blank control group. After the rabbits had been fed and administrated for a month, the pathologic changes, the levels of basic fibroblasts growth factors （bFGF）, epidermal growth factor （EGF） and intercellular adhesion molecule-1 （ICAM-1） in vitreous were observed respectively. Results Compared with model group, the contents of bFGF. EGF and ICAM-1 were decreased signifieantly in SanXueMingMu tablet group （ P 〈 0.01 ）. There was no significant change when compared with the content of EGF in blank group （P 〉 0.05）, while the levels of bFGF were higher than those of blank group （ P 〈 0.05）. The levels of bFGF. EGF and ICAM-1 in SanXueMingMu tablet group were lower than those in TaoHongSiWuTang and ZhuLingSan group. The PVR in SanXueMingMu tablet group was lighter than that in model group.TaoHongSiWuTang and ZhuLingSan group, respectively. Conclusion SanXueMingMu tablet could inhibit and cure the formation and development of traumatic PVR by decreasing the levels of bFGF.EGF and ICAM-1.

关 键 词：散血明目片 外伤性增生性玻璃体视网膜病变 碱性成纤维细胞生长因子表 皮生长因子 细胞间粘附分子-1 组织病理学 

分 类 号：R776.4[医药卫生—眼科]