Experimental study on therapy of ultraviolet blood irradiation and oxygenation in acute soman intoxication in rabbits  

作　　者：张献清 穆士杰 张晓迪 陈蕤 夏爱军 梁欣Department of Toxicology  Fourth Military Medical University  Xi'an 710032 China 海春旭Department of Toxicology  Fourth Military Medical University  Xi'an 710032 China 

机构地区：[1]Department of Blood Transfusion, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China [2]Department of Toxicology, Fourth Military Medical University, Xi'an 710032,China

出　　处：《Journal of Medical Colleges of PLA(China)》2005年第6期361-363,共3页中国人民解放军军医大学学报（英文版）

摘　　要：Objective:To study the therapy effect of ultraviolet blood irradiation and oxygenation （UBIO） on blood AChe activity and lung injury due to acute soman intoxication in rabbits. Methods:Forty rabbits were randomly divided into 4 groups: normal control group, intoxication group, routine therapy group and UBIO therapy group. Blood AChe activity and artery blood gas were analyzed 2 h after intoxication. ACP and AKP activities in BALF were determined respectively. Results:Blood AChe activity in intoxication group was lower than that in normal control group （P<0.05）. BALF ACP and AKP activities in intoxication group were higher than that in normal control group. Blood AChe activities in UBIO therapy group increased and were higher than that in intoxication and routine therapy groups. Compared with intoxication group, BALF ACP and AKP activities were decreased （P<0.05） in UBIO therapy group, while artery blood pH, PaO2 and SaO2 increased （P<0.05）. Conclusion: UBIO therapy can elevate blood AChe activity and alleviate lung injury induced by soman intoxication. So it may be a new way to treat acute soman intoxication.Objective： To study the therapy effect of ultraviolet blood irradiation and oxygenation （UBIO） on blood AChe activity and lung injury due to acute soman intoxication in rabbits. Methods ：Forty rabbits were randomly divided into 4 groups： normal control group, intoxication group, routine therapy group and UBIO therapy group. Blood AChe activity and artery blood gas were analyzed 2 h after intoxication. ACP and AKP activities in BALF were determined respectively. Results： Blood AChe activity in intoxication group was lower than that in normal control group （P〈0.05）. BALF ACP and AKP activities in intoxication group were higher than that in normal control group. Blood AChe activities in UBIO therapy group increased and were higher than that in intoxication and routine therapy groups. Compared with intoxication group, BALF ACP and AKP activities were decreased （P〈0. 05） in UBIO therapy group, while artery blood pH, PaO2 and SaO2 increased （P〈0. 05）. Conclusion.. UBIO therapy can elevate blood AChe activity and alleviate lung injury induced by soman intoxication. So it may be a new way to treat acute soman intoxication.

关 键 词：ultraviolet blood irradiation and oxygenation soman  lung injury ACETYLCHOLINESTERASE blood gas analysis 

分 类 号：R595.4[医药卫生—内科学]