大鼠海马伞切断Alzheimer病模型感觉门控P50的研究  

P50 auditory evoked potential in rat model of Alzheimer’s disease induced by fimbria-fornix transection

作　　者：朱榆红[1] 王廷华[2] 孙冰[1] 张卓[1] 晏燕[1] 韩志桐[2] 罗江兵[2] 

机构地区：[1]昆明医学院第二附属医院神经内科,云南省昆明市650031 [2]昆明医学院神经科学研究所,云南省昆明市650031

出　　处：《国际神经病学神经外科学杂志》2005年第6期491-494,共4页Journal of International Neurology and Neurosurgery

摘　　要：目的探讨Alzheimer病(AD)模型大鼠听觉P50诱发电位的变化及意义。方法通过双侧海马伞切断的方法建立AD大鼠模型。经Morris水迷宫行为学检测确定模型成功后,采用条件(C)试验(T)双声刺激模式记录听觉P50诱发电位,比较AD大鼠和正常及对照大鼠听觉P50诱发电位的差异。结果AD模型组表现:①条件刺激P50波幅(9.67±3.77)降低(P<0.01);②P50抑制减弱,T/C比(0.92±0.41)显著增高(P<0.01);③S2S1波幅的差(2.89±2.61)减小(P<0.01)。结论①AD大鼠存在感觉门控能力不足。②感觉门控P50作为一种反映大脑认知及注意力的指标,可能成为临床早期诊断和评价AD患者认知功能的一个新方法。Objective To observe the characteristics and significance of auditory evoked potential P50 in rat model of Alzheimer＇ s disease. Methods A rat model of Alzheimer＇ s disease was established by transecting bilateral fimbria-fornix and was proved successful by Morris water maze. Auditory evoked potential P50 was recorded by the conditioning/testing paradigm presented with auditory double clicks stimuli. The responses to auditory evoked potential were compared between the model and the normal groups as well as the control group （ cortex and corpus callosum were transected but the fimbria-fornix was not ）. Results In the rat model group, the amplitude of condition P50 response （ 9.67±3.77 ） was significantly lower than that of the normal group （ 17.04±5.32, P 〈0.01 ） and the control group （21.01±2.86）. The test/condition ratio （0.92±0.42 ） increased significantly com- pared with that of the normal group （0.39±0. 16, P 〈0.01 ） and the control group （0.25±0. 18, P 〈0.01 ）. The range of S2-S1 （2.89 ± 2.61 ） was significantly reduced compared with the normal （ 10.85±4.24, P 〈 0.01 ） and the control groups （ 15.26 ±4.07, P 〈 0.01 ）. Conclusions 1 ） There was a deficiency of sensory gating capability in rats with Alzheimer＇ s disease. 2） As a parameter reflecting cognition and attention, sensory gating PS0 might to be a new method for the early assessment of the function of cognition in patients with Alzheimer＇ s disease.

关 键 词：ALZHEIMER病 听觉诱发电位 P50 感觉门控 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R749.3[医药卫生—临床医学]