基质金属蛋白酶表达与胃癌侵袭、转移及生存期的关系  

Relationship between Expression of MMPs in Invasiveness and Metastasis of Gastric Carcinoma as well as Patients Survival.

作　　者：吴俊东[1] 庄业忠[1] 黄棉生[1] 黄文河[1] 洪超群[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院,515031

出　　处：《实用癌症杂志》2005年第5期487-489,共3页The Practical Journal of Cancer

摘　　要：目的探讨基质金属蛋白酶MMP-2、MMP-9、MMP-3在胃癌中的表达及其与侵袭、转移和生存期的关系。方法应用免疫组织化学SP法检测105例胃癌组织及60例相应癌转移淋巴结中MMP-2、MMP-9、MMP-3的表达情况。结果MMP-2、MMP-9、MMP-3在淋巴结转移灶的阳性表达率(分别为90.0%、88.3%、85.0%)显著高于胃癌组织中的阳性表达率(分别为72.4%、74.3%、71.4%)。三者表达强度与胃癌细胞分化程度无明显相关(P>0.05),而与胃癌的病期、浸润深度、淋巴结转移和远处转移密切相关(P<0.05)。MMP-9阳性表达者的5年生存率(22.7%)较阴性表达者(31.4%)低(P<0.05)。结论MMP-2、MMP-9、MMP-3表达与胃癌的浸润和淋巴结转移密切相关,MMP-9可作为患者预后有用的指标。Objective To investigate the MMPs expression in gastric carcinoma and their correlation with invasiveness and metastasis as well as patients survival. Methods Immunohistochemistry tecnique were use to examined the expression of MMP-2, MMP-9 and MMP-3 in 105 specimens of gastric carcinoma as well as 60 specimens with lymph node metastasis. Results The positive rate of MMP-2,MMP-9,MMP-3 expression in lymph node metastasis（90.0% ,88.3% ,85.0% respectively）were significantly higher than that in gastric carcinoma tissues（ 72.4% ,74.3% ,71.4% respectively）. No significant correlations were found between MMP-2, MMP-9, MMP-3 expression and tumour differentiation. In contrast,the intensity of MMP-2 , MMP-9, MMP-3 staining in tumour cells correlated significantly with depth of tumour infiltration（T-stage）,lymph node metastasis（N-stage）,distant metastasis （M-stage）,and UICC stage. Conclusion Expression of MMP-2 , MMP-9, MMP-3 is strongly associated with tumour progression and lymph node metastasis in gastric cancer. Therefore MMP-9 staining may be clinically useful as predictor of patients survival.

关 键 词：胃癌 免疫组织化学 基质金属蛋白酶 转移 

分 类 号：R735.2[医药卫生—肿瘤]