诱导型血红素氧合酶-1在溃疡性结肠炎结肠中的表达  

Expression of inducible heme oxygenase in colon of ulcerative colitis

作　　者：章明[1] 王启志[1] 高敏[2] 朱有法[3] 赵冬久[1] 

机构地区：[1]浙江大学医学院人体解剖学研究所,杭州310031 [2]浙江大学医学院附属邵逸夫医院消化科,杭州310031 [3]浙江大学医学院病理学教研室,杭州310031

出　　处：《浙江医学》2005年第12期896-898,共3页Zhejiang Medical Journal

基　　金：省科技厅基金资助项目(No.20030081)

摘　　要：目的研究诱导型血红素氧合酶-1(HO-1)在活动性溃疡性结肠炎(UC)患者结肠中的表达,探讨气体信使分子一氧化碳(CO)在UC发病机制中的可能作用。方法采用免疫组织化学SABC染色法,在符合临床和病理诊断标准的33例UC患者肠镜活检标本中分别检测结肠组织的HO-1的阳性细胞,并设立正常对照组。结果HO-1主要表达在结肠黏膜上皮细胞,UC患者表达明显强于对照组(P<0.01)。结论HO-1在UC患者结肠中的异常表达表明气信使分子CO在UC发病机制中可能起重要作用。Objective To detect the expression of heme oxygenase-1 （HO-1） in active ulcerative colitis （UC）. Methods Colon specimens were taken with colonoscopy from 33 cases of UC and 16 normal controls and the expression of HO-1 in colon tissue was detected by SABC immunohistochemistry. Results HO-1 was mainly detected in epithelia of colonic mucous membrane and the expression in UC group was stronger that than normal controls （P〈0.001）.Conclusion The abnormal expression of HO-1 in UC colon suggests that as important messenger molecule,CO may play an important role in the pathogenesis of inflammatory bowel diseases such as UC.

关 键 词：血红素氧合酶-1 一氧化碳 溃疡性结肠炎 免疫组织化学 

分 类 号：R574.6[医药卫生—消化系统]