慢性牙周炎非手术治疗前后龈沟液中CRP、sICAM-1含量比较  

The levels of C-reactive protein and soluble intercellular adhesion molecule-1 in the gingival crevicular fluid of chronic periodontitis

作　　者：罗志晓[1] 解晓琴[2] 周作华[2] 杨燕[1] 袁友国[1] 

机构地区：[1]郧阳医学院附属太和医院口腔科,湖北十堰442000 [2]郧阳医学院附属太和医院检验科,湖北十堰442000

出　　处：《郧阳医学院学报》2005年第6期342-344,共3页Journal of Yunyang Medical College

基　　金：十堰市科技攻关项目:2005031D

摘　　要：目的:测定慢性牙周炎龈沟液中CRP、sICAM-1的含量及牙周非手术治疗对其水平的影响。方法:选择22例中重度慢性牙周炎患者,进行牙周非手术治疗,并于治疗前后收集龈沟液,用ELISA法测定CRP、sICAM-1的水平,与正常对照组比较。结果:慢性牙周炎患者龈沟液CRP、sICAM-1水平较正常者增高(p<0.05);经牙周非手术治疗后,牙周临床指标明显改善,CRP、sICAM-1水平下降,接近牙周正常者水平(p<0.05)。结论:慢性牙周炎龈沟液CRP、sICAM-1的水平升高,牙周非手术治疗可有效地降低其在龈沟液中的表达。Objectives The aim of the present study was to determine whether the presence of chronic periodontitis and subsequent periodontal treatment could influence the gingival crevicular fluid （GCF） levels of C - reactive protein （CRP） and soluble intercellular adhesion molecule - 1 （ sICAM - 1 ）. Methods GCF was obtained from 22 patients with moderate to advanced chronic periodontitis at the baseline after completion of treatment. As a control, GCF was also obtained from 16 subjects without periodontitis. CRP and sICAM - 1 were determined by sensitive enzyme - linked immunosorbent assay. Results The levels of CRP and sICAM - 1 in the GCF of chronic periodontitis was higher than that in healthy control subjects. Periodontal status demonstrated a significant improvement in all patients following the treatment. CRP and sICAM - 1 concentration was reduced significantly with improvement of the periodontal condition following treatment and approached that of control subjects. Conclusions Periodontal disease significantly affects the levels of CRP and sICAM - 1 in the GCF.

关 键 词：慢性牙周炎 C反应蛋白 可溶性细胞间黏附分子1 龈沟液 

分 类 号：R781.4[医药卫生—口腔医学]