神经干细胞的迁移和网络化(英文)  

Migration and nerve net building of neural stem cells

作　　者：薛杉[1] 张旺明[1] 徐如祥[1] 

机构地区：[1]南方医科大学珠江医院神经外科,广东省广州市510282

出　　处：《中国临床康复》2005年第45期190-192,共3页Chinese Journal of Clinical Rehabilitation

基　　金：国家自然科研基金(3027049)~~

摘　　要：目的:从神经干细胞的迁移现象及其定向迁移的可能机制,神经网络的研究进展和神经干细胞迁移和网络化的意义等方面进行综述。资料来源押应用计算机检索Pubmed数据库1970/2004期间的相关文章,限定文章语言种类为English,检索词为“neuralstemcell,migration,nervenet”。资料选择押对资料进行初审,选取神经干细胞迁移和网络化的随机和非随机对照实验。排除综述类和重复的文章。资料提炼押共收集到相关文献39篇,共检出16篇文献涉及神经干细胞的迁移和网络化研究的进展,其余文献均被排除。资料综合:对于神经系统退行性病变及严重损伤,神经干细胞移植有可能替代衰老变性和死亡的神经细胞,重建神经网络,恢复失去的脑功能。神经细胞的迁移和网络化原理可以应用以解决神经干细胞移植后的存活、分化、迁移及神经网络建立的问题,实现脑功能修复重建。结论押神经干细胞在特定的情况下可以迁移到预计的地方并建立神经网络。OBJECTIVE： A series of recent studies have demonstrated the mecha- nism of migration and nerve net of neural stem cells. These theories have further substantiated neural stem cell transplantation. In view of these new findings, this paper reviewed the mode of migration and information of network. The significance of these theories was discussed. DATA SOURCE： We search on Pubmed with the key words ＂neural stem cell＂, ＂migration＂, and ＂nerve net＂, limiting the language to English and publication date from 1970 to 2004. At the same time we searched on CNKI. STUDY SELECTION： We selected the randomized and non-randomized controlled studies related to migration and nerve net building of neural stem cells. Review articles and articles with repetitive studies were excluded. DATA EXTRACTION： Among 39 papers selected, 16 papers concerning the development of this topic were selected, and the others were excluded. DATA SYNTHESIS： For retrograde lesions and severe injury of nervous system, transplantation of nerve stem cells may replace aging degenerative and dead nerve cells and rebuild neural network for the recovery of cerebral function. Migration of nerve cell and network principle can solve the survival, differentiation, migration and creation of nerve network after transplantation of nerve stem ceils so as to realize the recovery and reconstruction of cerebral function. CONCLUSION： Neural stem cells can migrate to intended places and can build nerve net under some conditions, which will be useful for medicine development.

关 键 词：干细胞 神经系统 文献综述 

分 类 号：R394.2[医药卫生—医学遗传学]