HLA-DRB1基因与子痫前期相关性研究  

Research on polymorphism of HLA-DRB1 in preeclampsia

作　　者：张展[1] 贾莉婷[1] 吴雄文[2] 侯磊[1] 熊平[2] 王雪梅[1] 常彩红[1] 龚非力[2] 

机构地区：[1]郑州大学第三附属医院,450052 [2]华中科技大学同济医学院,武汉430030

出　　处：《中华微生物学和免疫学杂志》2005年第12期979-983,共5页Chinese Journal of Microbiology and Immunology

基　　金：河南省科技攻关项目(524410022)

摘　　要：目的探讨HLA-DRB1基因与子痫前期相关性。方法采用序列特异性引物技术(PCR-SSP)对119例子痫前期患者、117例正常孕妇及其新生儿进行HLA-DRB1等位基因分型,比较其基因频率。结果共检出13种等位基因,两组孕母或两组新生儿间,其HLA-DRB1等位基因频率差异无统计学意义(Pc>0.05);子痫前期组和正常晚孕组母婴所携带HLA-DRB1*04、-DRB1*10、-DRB1*14等位基因配伍差异有统计学意义(P<0.05)。结论母婴所携带某些HLA-DRB1基因配伍与子痫前期易感性或抗性相关;父源性HLA-DRB1*04基因与子痫前期易感性相关。Objective To analyze the association between polymorphism of HIA-DRB1 genes and preeclampsia. Methods HL4-DRB1 genotyping was performed by polymerase chain reaction sequence-specific primer（PCR-SSP） in 119 preeclampsia patients, 117 normal pregnant women and their neonates. Results Thirteen alleles were obtained. There was not significant difference between preeclampsia group and control group （ Po 〉 0.05）. The frequencies of HL4-DRB1 ＊ 04, -DRB1＊ 10 and -DRB1 ＊ 14 maternal/fetus special bindings were significantly different between preectampsia group and control group（ P 〈 0.05）. Conclusion Some HIA-DRB1 maternal/fetus special bindings may be associated with the susceptibility or protective of pre-eelampsia. Paternal HIA-DRB 1 ＊ 04 may be a susceptible gene.

关 键 词：人类白细胞抗原 子痫前期 等位基因 多态性 

分 类 号：R714.246[医药卫生—妇产科学]